caa a22 4500 475753453 CHVBK 20180406123531.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s005950050598 doi (NATIONALLICENCE)springer-10.1007/s005950050598 Changes in Hepatic Venous Oxygen Saturation in Hepatic Warm Ischemia/Reperfusion Injury in Pigs [Elektronische Daten] [Tadashi Katsuramaki, Hitoshi Kimura, Masato Isobe, Minoru Nagayama, Makoto Meguro, Akihiro Nui, Takashi Matsuno, Hideki Ura, Mitsuhiro Mukaiya, Koichi Hirata] To clarify the changes that occur in hepatic venous oxygen saturation (Shvo2) during hepatic ischemia/reperfusion (I/R) injury, we examined the relationship between Shvo2, hepatic tissue blood flow (HTBF), and portal vein pressure (PVP) in a warm I/R model using pig livers. Female pigs weighing 18-23 kg were subjected to warm I/R under extracorporeal circulation between the superior mesentric vein and the left jugular vein to avoid portal congestion. The warm ischemic times were 120 min (n = 4), 180 min (n = 14), and 240 min (n = 4). Shvo2, HTBF, and PVP were measured after reperfusion. The survival rates of the pigs 3 days after reperfusion were 100% in the 120-min group, 57% in the 180-min group, and 25% in the 240-min group. In the 180-min group, the Shvo2 was lower in the pigs that died than in those that survived. There was a significant correlation between Shvo2 and both PVP and HTBF after reperfusion. Histological examination revealed findings of severe I/R injury in pigs with a low Shvo2, and mild I/R injury in pigs with a stable Shvo2. These observations suggest that the changes in Shvo2 could reflect the degree of hepatic I/R injury, especially that related to microcirculatory disturbances occurring at the sinusoid levels.: Springer-Verlag Tokyo, 2000 Key Words: hepatic venous oxygen saturation, ischemia/reperfusion injury, liver, pig nationallicence Katsuramaki Tadashi Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut Kimura Hitoshi Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut Isobe Masato Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut Nagayama Minoru Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut Meguro Makoto Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut Nui Akihiro Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut Matsuno Takashi Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut Ura Hideki Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut Mukaiya Mitsuhiro Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut Hirata Koichi Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut https://doi.org/10.1007/s005950050598 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950050598 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Katsuramaki Tadashi Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut NATIONALLICENCE 700 1- Kimura Hitoshi Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut NATIONALLICENCE 700 1- Isobe Masato Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut NATIONALLICENCE 700 1- Nagayama Minoru Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut NATIONALLICENCE 700 1- Meguro Makoto Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut NATIONALLICENCE 700 1- Nui Akihiro Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut NATIONALLICENCE 700 1- Matsuno Takashi Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut NATIONALLICENCE 700 1- Ura Hideki Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut NATIONALLICENCE 700 1- Mukaiya Mitsuhiro Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut NATIONALLICENCE 700 1- Hirata Koichi Department of Surgery (Section 1), Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer