caa a22 4500 475753488 CHVBK 20180406123531.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s005950070085 doi (NATIONALLICENCE)springer-10.1007/s005950070085 The time course of elastin fiber degeneration in a rat aneurysm model [Elektronische Daten] [Toshiyuki Yamaguchi, Masayasu Yokokawa, Mamoru Suzuki, Shinji Higashide, Yoshimasa Katoh, Shigeki Sugiyama, Takuro Misaki] Previous findings vary regarding the timing and cause of elastin fiber degeneration in the elastaseinduced rat abdominal aortic aneurysm model. We examined the timing and cause of elastin fiber degeneration after elastase infusion using two different elastase infusion times. Twenty-four Sprague-Dawley rats were divided into two groups. The infrarenal abdominal aorta was infused with 15 U of elastase for 15 min (n=12, 15-min infusion group) or 30min (n=12, 30-min infusion group). In each group, three rats were killed immediately and 1, 3, and 7 days after infusion, and then the aortas were excised for a histologic examination. Elastin fibers did not stain, even immediately after elastase infusion, in the 30-min infusion group. The degeneration of elastin fibers did not progress in the 15-min infusion group during the period of observation. Inflammatory cells infiltrated mainly to the adventitia near regions where the degeneration of elastin fibers spread totally through the aortic media. Elastin fibers degenerate immediately after elastase infusion and thus seem to degenerate not due to endogenous proteinases that are produced by the infiltrating cells, but due to the exogenously infused elastase itself. Inflammatory cell infiltration was thus found to be a result of the degeneration of elastin fibers in this model. Springer-Verlag, 2000 Elastin fiber nationallicence Elastase-induced rat aneurysm model nationallicence Yamaguchi Toshiyuki First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut Yokokawa Masayasu First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut Suzuki Mamoru First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut Higashide Shinji First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut Katoh Yoshimasa First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut Sugiyama Shigeki First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut Misaki Takuro First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut Surgery Today Springer-Verlag 30/8(2000-08-01), 727-731 0941-1291 30:8<727 2000 30 595 https://doi.org/10.1007/s005950070085 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070085 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamaguchi Toshiyuki First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Yokokawa Masayasu First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Suzuki Mamoru First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Higashide Shinji First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Katoh Yoshimasa First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Sugiyama Shigeki First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Misaki Takuro First Department of Surgery, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, 930-0194, Toyama, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/8(2000-08-01), 727-731 0941-1291 30:8<727 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer