caa a22 4500 475753518 CHVBK 20180406123531.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s005950070078 doi (NATIONALLICENCE)springer-10.1007/s005950070078 Nitrite/nitrate (NOx) levels and hemodynamics during septic shock [Elektronische Daten] [Hajime Nakae, Shigeatsu Endo, Mitsuru Kikuchi, Yasuhiko Yamada, Masashi Shibata, Hiroyasu Ishikura, Takaya Tanaka, Go Wakabayashi, Takae Kawamura, Katsuya Inada, Seidai Sato] Nitric oxide (NO) acts as a vasorelaxant. We investigated the relationship between nitrite/nitrate (NOx), which are the final metabolites of NO, and hemodynamics during septic shock. We also examined tumor necrosis factor α (TNF-α), interleukin-8 (IL-8), and endotoxin. A significant negative correlation was observed between NOx levels and pulmonary capillary wedge pressure (PCWP;r=−0.6075,P=0.0028). A significant positive correlation was noted between NOx levels and the cardiac index (CI;r=−0.5934,P=0.0038). A significant negative correlation was found between NOx levels and the systemic vascular resistance index (SVRI;r=−0.4354,P=0.0485). A significant positive correlation was observed between NOx levels and the stroke volume index (SVI;r=0.5040,P=0.0186). A significantly close positive correlation was also observed between TNF-α levels and NOx levels (r=0.7848,P<0.0001). These findings suggest that NOx levels are closely associated with hemodynamics during septic shock, resulting in a vascular relaxing effect. Springer-Verlag, 2000 Nitric oxide nationallicence Septic shock nationallicence Hemodynamics nationallicence Tumor necrosis factor α nationallicence Interleukin-8 nationallicence Nakae Hajime Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Endo Shigeatsu Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Kikuchi Mitsuru Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Yamada Yasuhiko Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Shibata Masashi Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Ishikura Hiroyasu Department of Emergency and Critical Care Medicine, Kansai Medical University, 10-12 Fumizonocho, Moriguchi, 570-0074, Osaka, Japan aut Tanaka Takaya Department of Emergency and Critical Care Medicine, Kansai Medical University, 10-12 Fumizonocho, Moriguchi, 570-0074, Osaka, Japan aut Wakabayashi Go Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-0016, Tokyo, Japan aut Kawamura Takae Memorial Heart Center, Iwate Medical University, 1-2-3 Chuodori, 020-0021, Morioka, Japan aut Inada Katsuya Department of Bacteriology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Sato Seidai Department of Bacteriology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut Surgery Today Springer-Verlag 30/8(2000-08-01), 683-688 0941-1291 30:8<683 2000 30 595 https://doi.org/10.1007/s005950070078 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070078 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakae Hajime Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Endo Shigeatsu Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Kikuchi Mitsuru Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Yamada Yasuhiko Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Shibata Masashi Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Ishikura Hiroyasu Department of Emergency and Critical Care Medicine, Kansai Medical University, 10-12 Fumizonocho, Moriguchi, 570-0074, Osaka, Japan aut NATIONALLICENCE 700 1- Tanaka Takaya Department of Emergency and Critical Care Medicine, Kansai Medical University, 10-12 Fumizonocho, Moriguchi, 570-0074, Osaka, Japan aut NATIONALLICENCE 700 1- Wakabayashi Go Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-0016, Tokyo, Japan aut NATIONALLICENCE 700 1- Kawamura Takae Memorial Heart Center, Iwate Medical University, 1-2-3 Chuodori, 020-0021, Morioka, Japan aut NATIONALLICENCE 700 1- Inada Katsuya Department of Bacteriology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 700 1- Sato Seidai Department of Bacteriology, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/8(2000-08-01), 683-688 0941-1291 30:8<683 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer