caa a22 4500 475753526 CHVBK 20180406123531.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s005950070079 doi (NATIONALLICENCE)springer-10.1007/s005950070079 Allelic loss on 17p13 (TP53) and allelic loss on 3p21 in early squamous cell carcinoma of the lung [Elektronische Daten] [Chiaki Endo, Masami Sato, Shigefumi Fujimura, Akira Sakurada, Hirokazu Aikawa, Satomi Takahashi, Katsuo Usuda, Yasuki Saito, Motoyasu Sagawa] Roentgenographically occult bronchogenic squamous cell carcinomas are early lung cancers that localize in the bronchial wall, and are thought to be a good model to elucidate the carcinogenesis of lung cancer. In the present study, we analyzed the incidence of allelic losses on chromosome regions 3p21 and 17p13 in 40 cases of roentgenographically occult bronchogenic squamous cell carcinomas, using three microsatellite dinucleotide polymorphic markers. We also investigated the relationship between such allelic loss and the clinicopathological findings of those cases. These chromosome regions showed frequent losses. Moreover, the incidence of loss on 17p13 increased gradually along with the advance of the depth of invasion, while the incidence of loss on 3p21 increased along with the advancing length of the longitudinal extension. These results suggested that these chromosome regions play different roles in lung cancer progression, i.e., the 3p21 chromosome region was related to the longitudinal extension of the carcinoma while the 17p13 (p53) region was related to the depth of invasion. Springer-Verlag, 2000 Roentgenographically occult lung cancer nationallicence Squamous cell carcinoma nationallicence Heterozygosity nationallicence Depth of invasion nationallicence Longitudinal extension nationallicence Endo Chiaki Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut Sato Masami Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut Fujimura Shigefumi Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut Sakurada Akira Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut Aikawa Hirokazu Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut Takahashi Satomi Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut Usuda Katsuo Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut Saito Yasuki Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut Sagawa Motoyasu Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut Surgery Today Springer-Verlag 30/8(2000-08-01), 695-699 0941-1291 30:8<695 2000 30 595 https://doi.org/10.1007/s005950070079 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070079 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Endo Chiaki Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Sato Masami Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Fujimura Shigefumi Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Sakurada Akira Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Aikawa Hirokazu Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Takahashi Satomi Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Usuda Katsuo Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Saito Yasuki Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Sagawa Motoyasu Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/8(2000-08-01), 695-699 0941-1291 30:8<695 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer