caa a22 4500 475753542 CHVBK 20180406123531.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s005950050041 doi (NATIONALLICENCE)springer-10.1007/s005950050041 An increase in macrophage migration inhibitory factor release in patients with cardiopulmonary bypass surgery [Elektronische Daten] [Satoshi Gando, Jun Nishihira, Osamu Kemmotsu, Shigeaki Kobayashi, Yuji Morimoto, Yoshiro Matsui, Keishu Yasuda] To determine the macrophage migration inhibitory factor (MIF) responses to cardiopulmonary bypass (CPB) surgery as well as to investigate their roles in predicting patient outcome, a prospective, observational, pilot study was performed. Thirty patients undergoing cardiovascular surgery with CPB received 10 mg/kg betamethasone immediately before the CPB. Ten normal healthy volunteers served as control subjects. Blood samples were serially obtained for 24 h and assayed for MIF, cortisol, and tumor necrosis factor α (TNF-α). TNF-α release could not be detected during the study period. Compared with both the control and baseline values, the MIF and cortisol levels were elevated before CPB and peaked at the end of CPB (57.5 ±4.8 ng/ml,P<0.0001), and at the end of the surgery (507.7±44.1 nmol/l,P , 0.0001), respectively. Peak MIF levels correlated with aortic cross-clamp time (r 2=0.183,P=0.0182,n=30), but did not show a significant correlation with peak cortisol levels. The levels of MIF tended to be 40%-50% higher during CPB in patients with longer intensive care unit (ICU) stays and in those with organ dysfunction than in those with short ICU stays and no organ dysfunction. All patients were discharged from the ICU. In conclusion, our findings demonstrate that MIF production occurs in patients with CPB surgery. When high-dose steroids are administered, high MIF levels were found to only slightly affect the patient morbidity and outcome after CPB surgery. Springer-Verlag, 2000 Cardiopulmonary bypass surgery nationallicence Cortisol nationallicence Macrophage migration inhibitory factor nationallicence Organ dysfunction nationallicence Outcome nationallicence Gando Satoshi Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut Nishihira Jun Central Research Institute, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut Kemmotsu Osamu Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut Kobayashi Shigeaki Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut Morimoto Yuji Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut Matsui Yoshiro Department of Cardiovascular Surgery, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut Yasuda Keishu Department of Cardiovascular Surgery, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut Surgery Today Springer-Verlag 30/8(2000-08-01), 689-694 0941-1291 30:8<689 2000 30 595 https://doi.org/10.1007/s005950050041 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950050041 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gando Satoshi Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Nishihira Jun Central Research Institute, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Kemmotsu Osamu Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Kobayashi Shigeaki Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Morimoto Yuji Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Matsui Yoshiro Department of Cardiovascular Surgery, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Yasuda Keishu Department of Cardiovascular Surgery, Hokkaido University School of Medicine, N15, W7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/8(2000-08-01), 689-694 0941-1291 30:8<689 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer