caa a22 4500 475753550 CHVBK 20180406123531.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s005950070077 doi (NATIONALLICENCE)springer-10.1007/s005950070077 Gastroduodenal lesions in familial adenomatous polyposis [Elektronische Daten] [Hiroshi Kashiwagi, Allan Spigelman] Prophylactic colectomy is generally recommended for patients with familial adenomatous polyposis (FAP) who are inevitably affected with large bowel cancer. After prophylactic colectomy has been performed, gastrointestinal malignancy is the leading cause of death. Duodenal adenomas are found in patients with FAP and the adenoma-carcinoma sequence exists in the FAP duodenum, suggesting that treatment of duodenal polyps might be beneficial. Several methods of treatment for duodenal lesions in patients with FAP have been reported, but the current treatment options are not ideal. The nonsteroid anti-inflammatory drugs, sulindac and aspirin, are used for chemoprevention, while recently developed cyclooxygenase-2 inhibitors may be of some use in the future. Endoscopic polypectomy has been attempted for duodenal polyps and open surgical polypectomy has proven to be effective for selected patients. Photodynamic therapy and Argon plasma coagulation may be suitable to treat carpeted polyposis. New methods of duodenal resection, such as pancreas-preserving duodenectomy and pyloruspreserving pancreaticoduodenectomy, might be considered for severe duodenal polyposis; however, because prophylactic duodenal surgery has been considered too aggressive, surveillance duodenoscopy is usually performed to detect duodenal cancer at an early stage. Springer-Verlag, 2000 Familial adenomatous polyposis nationallicence Duodenal polyp nationallicence Duodenal cancer nationallicence Surveillance nationallicence Kashiwagi Hiroshi Department of Surgery, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, 329-04, Tochigi, Japan aut Spigelman Allan Discipline of Surgical Science, Faculty of Medicine and Health Sciences, The University of Newcastle, Newcastle, NSW, Australia aut Surgery Today Springer-Verlag 30/8(2000-08-01), 675-682 0941-1291 30:8<675 2000 30 595 https://doi.org/10.1007/s005950070077 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070077 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kashiwagi Hiroshi Department of Surgery, Jichi Medical School, 3311-1 Yakushiji, Minami-kawachi, 329-04, Tochigi, Japan aut NATIONALLICENCE 700 1- Spigelman Allan Discipline of Surgical Science, Faculty of Medicine and Health Sciences, The University of Newcastle, Newcastle, NSW, Australia aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/8(2000-08-01), 675-682 0941-1291 30:8<675 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer