caa a22 4500 475753690 CHVBK 20180406123532.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s005950050612 doi (NATIONALLICENCE)springer-10.1007/s005950050612 Significant changes in the serum levels of IL-6, h-HGF, and type IV collagen 7S during the perioperative period of a hepatectomy: Relevance to SIRS [Elektronische Daten] [Koji Namekata, Shigeru Takamori, Kuniaki Kojima, Tomoe Beppu, Shunji Futagawa] We analyzed the changes in the serum levels of both interleukin-6 (IL-6), human hepatocyte growth factor (h-HGF), and type IV collagen 7S (7S) during the perioperative period of a hepatectomy and evaluated their relationship with systemic inflammatory response syndrome (SIRS). The study subjects consisted of 40 patients who underwent a hepatectomy. In 14 out of 40 patients, postoperative SIRS(+) was observed. Between the SIRS(+) and SIRS(− ) cases, there were significant differences in the preoperative values of prothrombin time, hepaplastin test, cholinesterase, and indocyanine green retention at 15 min (P < 0.01). Compared with the SIRS(−) cases, the IL-6, h-HGF, and 7S of the SIRS(1) cases fluctuated in a higher range and remained significantly higher after postoperative day 1 (P < 0.05). Eight out of 14 SIRS(+) patients had postoperative complications. In the 8 SIRS(+) patients with postoperative complications and in the 4 patients in which the SIRS(+) state lasted 3 days or longer, the 7S levels were significantly higher during the perioperative period (P < 0.05). In the SIRS(1) cases, the postoperative levels of IL-6 and h-HGF, as well as pre- and postoperative levels of 7S, were elevated. We therefore consider these levels to be risk factors for complications during the perioperative period of a hepatectomy. Springer-Verlag, 2000 interleukin-6 nationallicence human hepatocyte growth factor nationallicence type IV collagen 7S nationallicence systemic inflammatory response syndrome nationallicence Namekata Koji Second Department of Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Takamori Shigeru Second Department of Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Kojima Kuniaki Second Department of Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Beppu Tomoe Second Department of Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Futagawa Shunji Second Department of Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Surgery Today Springer-Verlag 30/5(2000-05-01), 403-409 0941-1291 30:5<403 2000 30 595 https://doi.org/10.1007/s005950050612 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950050612 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Namekata Koji Second Department of Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Takamori Shigeru Second Department of Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Kojima Kuniaki Second Department of Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Beppu Tomoe Second Department of Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Futagawa Shunji Second Department of Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 773 0- Surgery Today Springer-Verlag 30/5(2000-05-01), 403-409 0941-1291 30:5<403 2000 30 595 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer