caa a22 4500 475754050 CHVBK 20180406123533.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s005950050027 doi (NATIONALLICENCE)springer-10.1007/s005950050027 Altered Plasma Antigen Levels of Tissue Factor Pathway Inhibitor During Open-Heart Surgery [Elektronische Daten] [Ling-Bo Sun, Junichi Utoh, Ryuji Kunitomo, Shigeyuki Tsurusaki, Hirofumi Tagami, Tomomi Hirata, Shuji Moriyama, Ken Okamoto, Nobuo Kitamura] r: = 0.96, P < 0.0001) which increased significantly after heparin injection (P < 0.0001), and increased further during the bypass period (P < 0.005). The increased free TFPI antigen level during CPB correlated with the duration of bypass (r = 0.65, P = 0.02). When heparin was neutralized by protamine, the free TFPI antigen level decreased immediately, but remained higher than the preoperative level (P < 0.005). These results suggest that plasma TFPI antigen levels increase during CPB. Springer-Verlag Tokyo, 2000 Key Words: tissue factor pathway inhibitor, coagulation, cardiopulmonary bypass, open-heart surgery nationallicence Sun Ling-Bo First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut Utoh Junichi First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut Kunitomo Ryuji First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut Tsurusaki Shigeyuki First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut Tagami Hirofumi First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut Hirata Tomomi First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut Moriyama Shuji First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut Okamoto Ken First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut Kitamura Nobuo First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut https://doi.org/10.1007/s005950050027 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950050027 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sun Ling-Bo First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut NATIONALLICENCE 700 1- Utoh Junichi First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut NATIONALLICENCE 700 1- Kunitomo Ryuji First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut NATIONALLICENCE 700 1- Tsurusaki Shigeyuki First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut NATIONALLICENCE 700 1- Tagami Hirofumi First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut NATIONALLICENCE 700 1- Hirata Tomomi First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut NATIONALLICENCE 700 1- Moriyama Shuji First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut NATIONALLICENCE 700 1- Okamoto Ken First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut NATIONALLICENCE 700 1- Kitamura Nobuo First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer