caa a22 4500 475754212 CHVBK 20180406123533.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s005950070018 doi (NATIONALLICENCE)springer-10.1007/s005950070018 Deterioration of Visceral Perfusion Caused by Intra-Abdominal Hypertension in Pigs Ventilated with Positive End-Expiratory Pressure [Elektronische Daten] [Katerina Kotzampassi, Danos Paramythiotis, Efthimios Eleftheriadis] Experimental studies and clinical experience suggest that the combination of positive end-expiratory pressure (PEEP) ventilation and intra-abdominal hypertension might alter splanchnic hemodynamics to a significantly greater degree than the effect of either of them alone. Therefore, we assessed the intestinal and hepatic hemodynamics in two steps of PEEP ventilation, adding tense pneumoperitoneum in a pig model. The hepatic artery, portal vein, and superior mesenteric artery blood flow, as well as the hepatic and intestinal mucosal microcirculation, and the hepatic pO2 and intestinal mucosal pH, were assessed before, then with 5 cmH2O and 10 cmH2O PEEP alone, and in com-bination with a 12-mmHg pneumoperitoneum, in ten domestic pigs. Statistical analysis of the hepatic and intestinal measurements revealed a significant decrease (P = 0.001) in all parameters in relation to the baseline, during the 5-cmH2O and 10-mmH2O PEEP ventilation period. The addition of 12 mmHg intra-abdominal pressure led to an extreme deterioration in all parameters (P = 0.001), in relation to both the baseline and the 10-cmH2O PEEP measurement. These findings demonstrate that PEEP and intra-abdominal hypertension act cumulatively on the abdominal viscera, producing conditions of extremely low hypoperfusion and ischemia. Springer-Verlag, 2000 Key words Intra-abdominal pressure nationallicence Abdominal compartment syndrome nationallicence Positive end-expiratory pressure nationallicence Pneumoperitoneum nationallicence Kotzampassi Katerina Department of Surgery, University of Thessaloniki, Medical School, GR-54006 Thessaloniki, Greece, GR aut Paramythiotis Danos Department of Surgery, University of Thessaloniki, Medical School, GR-54006 Thessaloniki, Greece, GR aut Eleftheriadis Efthimios Department of Surgery, University of Thessaloniki, Medical School, GR-54006 Thessaloniki, Greece, GR aut https://doi.org/10.1007/s005950070018 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070018 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kotzampassi Katerina Department of Surgery, University of Thessaloniki, Medical School, GR-54006 Thessaloniki, Greece, GR aut NATIONALLICENCE 700 1- Paramythiotis Danos Department of Surgery, University of Thessaloniki, Medical School, GR-54006 Thessaloniki, Greece, GR aut NATIONALLICENCE 700 1- Eleftheriadis Efthimios Department of Surgery, University of Thessaloniki, Medical School, GR-54006 Thessaloniki, Greece, GR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer