caa a22 4500 47575428X CHVBK 20180406123533.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s005950070015 doi (NATIONALLICENCE)springer-10.1007/s005950070015 Gene Therapy for Cancer [Elektronische Daten] [Yoshio Gunji, Takenori Ochiai, H. Shimada, H. Matsubara] The basic strategies for gene therapy that have been explored include immunogene therapy such as cytokine gene transfer, selective prodrug activation, so-called suicide genes, transfer of a tumor suppressor gene, and inhibition of activated oncogenes by antisense mechanisms. Many therapeutic protocols have so far been registered in the office of the Recombinant DNA Advisory Committee, NIH, as of June 1999. Regarding the basic research in gene therapy, we planned a clinical application of gene therapy for an esophageal cancer patient at our institution. We review herein the present status of gene therapy for cancer overseas, and describe a protocol of clinical trials for gene therapy for esophageal cancer at our institution. Springer-Verlag, 2000 Key words Gene therapy nationallicence Cancer nationallicence Esophagus nationallicence Gunji Yoshio Second Department of Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, JP aut Ochiai Takenori Second Department of Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, JP aut Shimada H. Second Department of Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, JP aut Matsubara H. Second Department of Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, JP aut https://doi.org/10.1007/s005950070015 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005950070015 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gunji Yoshio Second Department of Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, JP aut NATIONALLICENCE 700 1- Ochiai Takenori Second Department of Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, JP aut NATIONALLICENCE 700 1- Shimada H. Second Department of Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, JP aut NATIONALLICENCE 700 1- Matsubara H. Second Department of Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer