caa a22 4500 475754565 CHVBK 20180406123534.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s002470050768 doi (NATIONALLICENCE)springer-10.1007/s002470050768 Hepatic regenerating nodules: a mimic of recurrent cancer in children [Elektronische Daten] [H. Brisse, V. Servois, B. Bouche, F. Avni, P. Petit, F. Thibault, J. -M. Zucker, C. Devalck, S. Neuenschwander] Background. Pseudometastatic lesions of the liver may be discovered incidentally in children previously treated for malignant tumour.¶Objective. To describe the radiological pattern of these lesions and to analyse their pathogenesis.¶Materials and methods. Nine children, 2-12 years' old at the time of diagnosis, are described in this retrospective multicentre report. The primary tumours were: nephroblastoma (n = 2), neuroblastoma (n = 2), Ewing's tumour/PNET (n = 2), non-Hodgkin's lymphoma (n = 1), and osteosarcoma (n = 2), treated by surgery (8/9), chemotherapy (9/9), intensive chemotherapy and bone-marrow transplantation (5/9), and radiotherapy (7/9). Three children suffered veno-occlusive disease (VOD) during treatment. The hepatic assessment was performed by sonography (8/9), Doppler (7/9), multiphase spiral CT (8/9) and MRI (7/9).¶Results. Lesions were discovered 15 months to 16 years after completing treatment. CT was the most sensitive modality for diagnosis. Lesions were multiple in eight cases, measured 2-50 mm, and appeared hypervascular on the arterial phase of CT and/or MRI in every case. Metastases were excluded on the basis of histological verification (n = 2) and clinical and radiological follow-up.¶Conclusion. Pseudometastatic hypervascular hepatic nodules can appear after treatment of a malignant tumour in children. The hypothesis of benign regenerative lesions secondary to treatment and/or VOD is considered. Springer-Verlag Berlin Heidelberg, 2000 Brisse H. Department of Radiology, Institut Curie, 26 rue d'Ulm, 75 005 Paris, France, FR aut Servois V. Department of Radiology, Institut Curie, 26 rue d'Ulm, 75 005 Paris, France, FR aut Bouche B. Department of Radiology, HUDERF, Brussels, Belgium, BE aut Avni F. Department of Radiology, HUDERF, Brussels, Belgium, BE aut Petit P. Department of Radiology, Hôpital d'Enfants de la Timone, Marseille, France, FR aut Thibault F. Department of Radiology, Institut Curie, 26 rue d'Ulm, 75 005 Paris, France, FR aut Zucker J. -M Department of Paediatric Oncology, Institut Curie, Paris, France, FR aut Devalck C. Department of Paediatric Oncology, HUDERF, Brussels, Belgium, BE aut Neuenschwander S. Department of Radiology, Institut Curie, 26 rue d'Ulm, 75 005 Paris, France, FR aut https://doi.org/10.1007/s002470050768 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002470050768 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brisse H. Department of Radiology, Institut Curie, 26 rue d'Ulm, 75 005 Paris, France, FR aut NATIONALLICENCE 700 1- Servois V. Department of Radiology, Institut Curie, 26 rue d'Ulm, 75 005 Paris, France, FR aut NATIONALLICENCE 700 1- Bouche B. Department of Radiology, HUDERF, Brussels, Belgium, BE aut NATIONALLICENCE 700 1- Avni F. Department of Radiology, HUDERF, Brussels, Belgium, BE aut NATIONALLICENCE 700 1- Petit P. Department of Radiology, Hôpital d'Enfants de la Timone, Marseille, France, FR aut NATIONALLICENCE 700 1- Thibault F. Department of Radiology, Institut Curie, 26 rue d'Ulm, 75 005 Paris, France, FR aut NATIONALLICENCE 700 1- Zucker J. -M Department of Paediatric Oncology, Institut Curie, Paris, France, FR aut NATIONALLICENCE 700 1- Devalck C. Department of Paediatric Oncology, HUDERF, Brussels, Belgium, BE aut NATIONALLICENCE 700 1- Neuenschwander S. Department of Radiology, Institut Curie, 26 rue d'Ulm, 75 005 Paris, France, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer