caa a22 4500 47575509X CHVBK 20180406123535.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s002470000223 doi (NATIONALLICENCE)springer-10.1007/s002470000223 Prospective assessment of pituitary size and shape on MR imaging after suppressive hormonal therapy in central precocious puberty [Elektronische Daten] [J. T. Van Beek, M. J. A. Sharafuddin, S. C. S. Kao, A. Luisiri, L. R. Garibaldi] Objective. The diagnostic significance of an enlarged pituitary gland regarding both shape and size parameters on MR imaging has previously been demonstrated in children with central precocious puberty. This study was designed to assess changes in these parameters following successful suppressive therapy of central precocious puberty with the gonadotropin-releasing hormone (GnRH) analogue.¶Materials and methods. Twelve girls (mean age 7.3 years) with central precocious puberty were prospectively enrolled in our study protocol. Sagittal and coronal MR images of the pituitary region were obtained in all patients before treatment and after at least 6 months of GnRH analogue therapy (mean 18.0 months). Parameters measured included pituitary gland height, length, width, sagittal cross-sectional area, and volume.¶Results. All patients had excellent clinical response to treatment with arrest of secondary sexual development, normalization of serum estradiol levels, and complete obliteration of the LH response to diagnostic GnRH stimulation. No significant change occurred in any pituitary size or shape parameter following GnRH analogue therapy.¶Conclusion. Favorable clinical response to GnRH analogue therapy in central precocious puberty is not accompanied by significant a change in pituitary gland size and shape. Springer-Verlag Berlin Heidelberg, 2000 Van Beek J. T. Department of Radiology-JPP 3889, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52246, USA, US aut Sharafuddin M. J. A. Department of Radiology-JPP 3889, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52246, USA, US aut Kao S. C. S. Department of Radiology-JPP 3889, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52246, USA, US aut Luisiri A. Cardinal Glennon Children's Hospital, St. Louis, Missouri, USA, US aut Garibaldi L. R. Children's Hospital of New Jersey, Newark Beth Israel Medical Center, Newark, New Jersey, USA, US aut https://doi.org/10.1007/s002470000223 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002470000223 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Van Beek J. T. Department of Radiology-JPP 3889, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52246, USA, US aut NATIONALLICENCE 700 1- Sharafuddin M. J. A. Department of Radiology-JPP 3889, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52246, USA, US aut NATIONALLICENCE 700 1- Kao S. C. S. Department of Radiology-JPP 3889, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52246, USA, US aut NATIONALLICENCE 700 1- Luisiri A. Cardinal Glennon Children's Hospital, St. Louis, Missouri, USA, US aut NATIONALLICENCE 700 1- Garibaldi L. R. Children's Hospital of New Jersey, Newark Beth Israel Medical Center, Newark, New Jersey, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer