caa a22 4500 475755219 CHVBK 20180406123536.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s002470000342 doi (NATIONALLICENCE)springer-10.1007/s002470000342 CT imaging of splenic sequestration in sickle cell disease [Elektronische Daten] [S. Sheth, C. Ruzal-Shapiro, S. Piomelli, W. E. Berdon] Pooling of blood in the spleen is a frequent occurrence in children with sickle cell diseases, particularly in the first few years of life, resulting in what is termed "splenic sequestration crisis.” The spectrum of severity in this syndrome is wide, ranging from mild splenomegaly to massive enlargement, circulatory collapse, and even death. The diagnosis is usually clinical, based on the enlargement of the spleen with a drop in hemoglobin level by > 2 g/dl, and it is rare that imaging studies are ordered. However, in the patient who presents to the emergency department with non-specific findings of an acute abdomen, it is important to recognize the appearance of sequestration on imaging studies. We studied seven patients utilizing contrast-enhanced CT scans and found two distinct patterns - multiple, peripheral, non-enhancing low-density areas or large, diffuse areas of low density in the majority of the splenic tissue. Although radiological imaging is not always necessary to diagnose splenic sequestration, in those situations where this diagnosis is not immediately obvious, it makes an important clarifying contribution. Springer-Verlag Berlin Heidelberg, 2000 Sheth S. Division of Pediatric Hematology, Department of Pediatrics, Division of Hematology, College of Physicians and Surgeons of Columbia University, 622 West 168th Street, New York, NY 10032, USA e-mail: ss125@columbia.edu Tel.: + 1-2 12-3 05 84 95, US aut Ruzal-Shapiro C. Division of Pediatric Radiology, Department of Radiology, College of Physicians and Surgeons of Columbia University, New York, NY, USA e-mail: Berdonw@cpmc3.cis.columbia.edu, US aut Piomelli S. Division of Pediatric Hematology, Department of Pediatrics, Division of Hematology, College of Physicians and Surgeons of Columbia University, 622 West 168th Street, New York, NY 10032, USA e-mail: ss125@columbia.edu Tel.: + 1-2 12-3 05 84 95, US aut Berdon W. E. Division of Pediatric Radiology, Department of Radiology, College of Physicians and Surgeons of Columbia University, New York, NY, USA e-mail: Berdonw@cpmc3.cis.columbia.edu, US aut https://doi.org/10.1007/s002470000342 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002470000342 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sheth S. Division of Pediatric Hematology, Department of Pediatrics, Division of Hematology, College of Physicians and Surgeons of Columbia University, 622 West 168th Street, New York, NY 10032, USA e-mail: ss125@columbia.edu Tel.: + 1-2 12-3 05 84 95, US aut NATIONALLICENCE 700 1- Ruzal-Shapiro C. Division of Pediatric Radiology, Department of Radiology, College of Physicians and Surgeons of Columbia University, New York, NY, USA e-mail: Berdonw@cpmc3.cis.columbia.edu, US aut NATIONALLICENCE 700 1- Piomelli S. Division of Pediatric Hematology, Department of Pediatrics, Division of Hematology, College of Physicians and Surgeons of Columbia University, 622 West 168th Street, New York, NY 10032, USA e-mail: ss125@columbia.edu Tel.: + 1-2 12-3 05 84 95, US aut NATIONALLICENCE 700 1- Berdon W. E. Division of Pediatric Radiology, Department of Radiology, College of Physicians and Surgeons of Columbia University, New York, NY, USA e-mail: Berdonw@cpmc3.cis.columbia.edu, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer