caa a22 4500 475755413 CHVBK 20180406123536.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s002470050045 doi (NATIONALLICENCE)springer-10.1007/s002470050045 Unusual findings in two cases of Langerhans' cell histiocytosis [Elektronische Daten] [N. Damry, N. Hottat, N. Azzi, A. Ferster, F. Avni] We report unusual findings in two patients with Langerhans' cell histiocytosis (LCH), namely a cervical mass lesion with extensive destruction of the posterior elements of a cervical vertebra and gastrointestinal lesions as part of multisystem involvement. The aim of our report is threefold. Firstly, LCH can be responsible for osteolysis of the vertebral posterior arches, with or without involvement of the vertebral body, and should be included in the differential diagnoses of cervical mass lesions. Secondly, in a patient with confirmed LCH and additional protein-losing enteropathy, gastrointestinal involvement should be considered as a possibility since it is an important factor for establishing prognosis. Thirdly, LCH lesions can be very extensive and yet have a good response to therapy, whereas less spectacular lesions may not respond or respond only partially to therapy. Thus, an important factor in establishing prognosis is the presence of multisystem involvement at diagnosis, regardless of the extent of a lesion at a particular site. Springer-Verlag Berlin Heidelberg, 2000 Damry N. Department of Radiology, Hôpital Universitaire des Enfants Reine Fabiola, 15 av. J. J. Crocq, 1020 Brussels, Belgium, BE aut Hottat N. Department of Radiology, Hôpital Universitaire des Enfants Reine Fabiola, 15 av. J. J. Crocq, 1020 Brussels, Belgium, BE aut Azzi N. Department of Oncology, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium, BE aut Ferster A. Department of Oncology, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium, BE aut Avni F. Department of Radiology, Hôpital Universitaire des Enfants Reine Fabiola, 15 av. J. J. Crocq, 1020 Brussels, Belgium, BE aut https://doi.org/10.1007/s002470050045 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002470050045 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Damry N. Department of Radiology, Hôpital Universitaire des Enfants Reine Fabiola, 15 av. J. J. Crocq, 1020 Brussels, Belgium, BE aut NATIONALLICENCE 700 1- Hottat N. Department of Radiology, Hôpital Universitaire des Enfants Reine Fabiola, 15 av. J. J. Crocq, 1020 Brussels, Belgium, BE aut NATIONALLICENCE 700 1- Azzi N. Department of Oncology, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium, BE aut NATIONALLICENCE 700 1- Ferster A. Department of Oncology, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium, BE aut NATIONALLICENCE 700 1- Avni F. Department of Radiology, Hôpital Universitaire des Enfants Reine Fabiola, 15 av. J. J. Crocq, 1020 Brussels, Belgium, BE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer