caa a22 4500 475755588 CHVBK 20180406123537.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s002470000290 doi (NATIONALLICENCE)springer-10.1007/s002470000290 Incidence of focal white matter lesions in a population of hemophiliac children and their normal siblings [Elektronische Daten] [M. D. Nelson Jr., D. A. Wilson, C. T. Kisker, B. L. Evatt, M. J. Fenstermacher, H. S. Lynn, S. M. Donfield, M. A. Maeder] Objective. This analysis was undertaken to evaluate the etiology and sequelae of 2- to 5-mm focal white matter hyperintensities on T2-weighted MR images of some participants enrolled in the Hemophilia Growth and Development Study (HGDS).¶Materials and methods. The HGDS is a multicenter study of the growth and development, neurological, neuropsychological, and immune functioning of a cohort of children and adolescents, 62 % of whom were infected with HIV through the use of clotting factor concentrates, and their non-hemophiliac, non-HIV infected male siblings. The current investigation was conducted with all three groups of HGDS participants: HIV-positive hemophiliacs (n = 207), HIV-negative hemophiliacs (n = 126), and their siblings (n = 47). Magnetic resonance imaging was performed at each center, with a variety of 0.3 to 1.5 T instruments. Standard examinations included 5-mm-thick T1-weighted sagittal and axial images, intermediate, and T2-weighted axial images. A study of abnormalities of the coagulation system known to be associated with thrombotic events was conducted among a subgroup of participants (n = 51) from eight centers.¶Results. Lesions were not associated with hemophilia-related factors, immune function, hematologic, or neurologic factors. There were no associations between the presence of white matter lesions and defects of coagulation in any of the assays completed.¶Conclusion. The 2- to 5-mm focal white matter hyperintensities on T2-weighted MR images of the brain were incidental findings in our study population. Springer-Verlag Berlin Heidelberg, 2000 Nelson Jr. M. D. Department of Radiology, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, MS81, Los Angeles, California 90027, USA e-mail: mdnelson@chla.usc.edu Tel.: + 1-3 23-6 69 45 72 Fax: + 1-3 23-6 66 46 55, US aut Wilson D. A. Magnetic Resonance Center of Oklahoma, Childrens Hospital of Oklahoma, Oklahoma City, Oklahoma, USA, US aut Kisker C. T. Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, USA, US aut Evatt B. L. Centers for Disease Control and Prevention, Atlanta, Georgia, USA, US aut Fenstermacher M. J. M.D. Anderson Cancer Center, Houston, Texas, USA, US aut Lynn H. S. Rho, Inc., Chapel Hill, North Carolina, USA, US aut Donfield S. M. Rho, Inc., Chapel Hill, North Carolina, USA, US aut Maeder M. A. Parexel, San Diego, California, USA, US aut https://doi.org/10.1007/s002470000290 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002470000290 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nelson Jr M. D. Department of Radiology, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, MS81, Los Angeles, California 90027, USA e-mail: mdnelson@chla.usc.edu Tel.: + 1-3 23-6 69 45 72 Fax: + 1-3 23-6 66 46 55, US aut NATIONALLICENCE 700 1- Wilson D. A. Magnetic Resonance Center of Oklahoma, Childrens Hospital of Oklahoma, Oklahoma City, Oklahoma, USA, US aut NATIONALLICENCE 700 1- Kisker C. T. Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa, USA, US aut NATIONALLICENCE 700 1- Evatt B. L. Centers for Disease Control and Prevention, Atlanta, Georgia, USA, US aut NATIONALLICENCE 700 1- Fenstermacher M. J. M.D. Anderson Cancer Center, Houston, Texas, USA, US aut NATIONALLICENCE 700 1- Lynn H. S. Rho, Inc., Chapel Hill, North Carolina, USA, US aut NATIONALLICENCE 700 1- Donfield S. M. Rho, Inc., Chapel Hill, North Carolina, USA, US aut NATIONALLICENCE 700 1- Maeder M. A. Parexel, San Diego, California, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer