caa a22 4500 475755685 CHVBK 20180406123537.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s002470000304 doi (NATIONALLICENCE)springer-10.1007/s002470000304 Initial experience with intravenous pentobarbital sedation for children undergoing MRI at a tertiary care pediatric hospital: the learning curve [Elektronische Daten] [S. B. Greenberg, R. C. Adams, C. L. Aspinall] Objective. Our purpose is to describe the initial experience with intravenous pentobarbital sedation in children undergoing MRI at a tertiary pediatric hospital to identify errors associated with inexperience.¶Subjects and methods. The study included the first 100 children sedated with intravenous pentobarbital prior to magnetic resonance examination at a tertiary pediatric hospital. The protocol included a maximum dose of 6 mg/kg administered in three divided doses with the total dose not to exceed 200 mg. Flow sheets documenting vital signs, administered drug doses, and adverse reactions were maintained contemporaneous to sedation.¶Results. Sedation was successful in 92 children. Of the eight children who failed sedation, three were at least 12 years old and three weighed more than 50 kg. χ 2 tests identified significantly greater failure rates in children older than 11 years or weight greater than 50 kg. Two children had prolonged sedation after the maximum suggested dose was exceeded.¶Conclusions. The success rate was good, but could have been improved by restricting the use of pentobarbital to children less than 12 years of age and weighing less than 50 kg. Radiologists inexperienced with intravenous sedation should strictly observe the maximum suggested dose of pentobarbital to prevent prolonged sedation. Springer-Verlag Berlin Heidelberg, 2000 Greenberg S. B. Arkansas Children's Hospital, 800 Marshall Street, Little Rock, AR 72202, USA e-mail: GreenbergSBruce@exchange.UAMS.edu Tel.: + 1-5 01-3 20 49 48 Fax: + 1-5 01-3 20 15 13, US aut Adams R. C. St. Christopher's Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA, US aut Aspinall C. L. St. Christopher's Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA, US aut https://doi.org/10.1007/s002470000304 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002470000304 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Greenberg S. B. Arkansas Children's Hospital, 800 Marshall Street, Little Rock, AR 72202, USA e-mail: GreenbergSBruce@exchange.UAMS.edu Tel.: + 1-5 01-3 20 49 48 Fax: + 1-5 01-3 20 15 13, US aut NATIONALLICENCE 700 1- Adams R. C. St. Christopher's Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA, US aut NATIONALLICENCE 700 1- Aspinall C. L. St. Christopher's Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer