caa a22 4500 475756053 CHVBK 20180406123538.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s002470050743 doi (NATIONALLICENCE)springer-10.1007/s002470050743 Accuracy of MR imaging for detecting epiphyseal extension of osteosarcoma [Elektronische Daten] [F. A. Hoffer, Alexander Y. Nikanorov, Wilburn E. Reddick, Sara M. Bodner, Xiaoping Xiong, Dana Jones-Wallace, Suzanne A. Gronemeyer, Bhaskar N. Rao, William M. Kauffman, Tal Laor] Background. Too few patients are receiving epiphyseal-sparing limb salvage procedures for osteosarcoma. Objective. To determine how magnetic resonance (MR) imaging can best predict the epiphyseal extension of osteosarcoma. Materials and methods. Forty children underwent complete pretreatment static and dynamic contrast-enhanced MR imaging (DEMRI). Static MR images [T1-weighted and short tau inversion recovery (STIR)] of the epiphyses were read in three ways: (1) for suspicion of any abnormality (tumor or edema), (2) for suspicion of tumor, excluding suspected edema, and (3) validating the second method by using a scale to rate the likelihood of tumor. Presentation imaging was compared to histopathologic findings after chemotherapy and resection. The receiver operating characteristic (ROC) method was used to analyze the scaled ratings of static MR and DEMRI values. Results. At delayed resection, 20 of 40 children with osteosarcoma had confirmed epiphyseal tumor; however, 32 epiphyses were abnormal on STIR and 28 abnormal on T1. Differentiating suspected tumor from edema increased the accuracy to an Az (area under the ROC curve) of 0.94 for both T1-weighted and STIR static sequences. T1-weighted MR had better specificity and STIR better sensitivity at any given rating. DEMRI was slightly less accurate (Az = 0.90). Conclusion. Static MR imaging most accurately detected epiphyseal extension of osteosarcoma when readers distinguished suspected tumor from edematous or normal tissue. Springer-Verlag Berlin Heidelberg, 2000 Hoffer F. A. Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 322 N. Lauderdale St., Memphis TN 38105-2794, USA, US aut Nikanorov Alexander Y. Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 322 N. Lauderdale St., Memphis TN 38105-2794, USA, US aut Reddick Wilburn E. Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 322 N. Lauderdale St., Memphis TN 38105-2794, USA, US aut Bodner Sara M. Department of Pathology, St. Jude Children's Research Hospital, Memphis TN, USA, US aut Xiong Xiaoping Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA, US aut Jones-Wallace Dana Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA, US aut Gronemeyer Suzanne A. Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 322 N. Lauderdale St., Memphis TN 38105-2794, USA, US aut Rao Bhaskar N. Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA, US aut Kauffman William M. Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 322 N. Lauderdale St., Memphis TN 38105-2794, USA, US aut Laor Tal Department of Radiology, Children's Hospital Medical Center, Cincinnati, OH, USA, US aut https://doi.org/10.1007/s002470050743 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002470050743 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hoffer F. A. Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 322 N. Lauderdale St., Memphis TN 38105-2794, USA, US aut NATIONALLICENCE 700 1- Nikanorov Alexander Y. Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 322 N. Lauderdale St., Memphis TN 38105-2794, USA, US aut NATIONALLICENCE 700 1- Reddick Wilburn E. Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 322 N. Lauderdale St., Memphis TN 38105-2794, USA, US aut NATIONALLICENCE 700 1- Bodner Sara M. Department of Pathology, St. Jude Children's Research Hospital, Memphis TN, USA, US aut NATIONALLICENCE 700 1- Xiong Xiaoping Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA, US aut NATIONALLICENCE 700 1- Jones-Wallace Dana Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA, US aut NATIONALLICENCE 700 1- Gronemeyer Suzanne A. Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 322 N. Lauderdale St., Memphis TN 38105-2794, USA, US aut NATIONALLICENCE 700 1- Rao Bhaskar N. Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA, US aut NATIONALLICENCE 700 1- Kauffman William M. Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 322 N. Lauderdale St., Memphis TN 38105-2794, USA, US aut NATIONALLICENCE 700 1- Laor Tal Department of Radiology, Children's Hospital Medical Center, Cincinnati, OH, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer