caa a22 4500 47575607X CHVBK 20180406123538.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s002470050759 doi (NATIONALLICENCE)springer-10.1007/s002470050759 Myocardial perfusion in children with sickle cell anaemia [Elektronische Daten] [Philippe Acar, Stéphane Sébahoun, Loïc de Pontual, C. Maunoury] Background. Myocardial ischaemia is an unexpected complication with potentially serious clinical damages in patients with sickle cell anaemia (SCA). Conventional techniques, such as exercise testing and echocardiography, have low sensitivity and specificity for the detection of myocardial ischaemia in patients with SCA. Objective. To assess myocardial perfusion using thallium-201 (201Tl) single-photon emission computed tomography (SPECT) in children with SCA. Materials and methods. Eight patients (11.5 ± 5.0 years, mean ± SD) who were free of cardiac symptoms were studied. Myocardial perfusion was assessed by 201Tl-SPECT after stress and 3 h later after a further injection. Left ventricular ejection fraction (LVEF) was assessed by equilibrium radionuclide angiography. Results. Myocardial perfusion was abnormal in three of eight patients: two had reversible defects and one had a fixed defect. The mean LVEF was 53 ± 8 %. There was no relationship between myocardial perfusion and LVEF. Conclusions. Treatment of asymptomatic myocardial ischaemia remains unclear, and more aggressive therapy of the haematological disease should be considered. Springer-Verlag Berlin Heidelberg, 2000 Acar Philippe Service de Cardiologie Pédiatrique, Hôpital Necker - Enfants Malades, Paris, France, FR aut Sébahoun Stéphane Service de Médecine Nucléaire, Hôpital Necker - Enfants Malades, 149 rue de Sèvres, 75 743 Paris Cedex 15, France, FR aut de Pontual Loïc Service de Cardiologie Pédiatrique, Hôpital Necker - Enfants Malades, Paris, France, FR aut Maunoury C. Service de Médecine Nucléaire, Hôpital Necker - Enfants Malades, 149 rue de Sèvres, 75 743 Paris Cedex 15, France, FR aut https://doi.org/10.1007/s002470050759 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002470050759 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Acar Philippe Service de Cardiologie Pédiatrique, Hôpital Necker - Enfants Malades, Paris, France, FR aut NATIONALLICENCE 700 1- Sébahoun Stéphane Service de Médecine Nucléaire, Hôpital Necker - Enfants Malades, 149 rue de Sèvres, 75 743 Paris Cedex 15, France, FR aut NATIONALLICENCE 700 1- de Pontual Loïc Service de Cardiologie Pédiatrique, Hôpital Necker - Enfants Malades, Paris, France, FR aut NATIONALLICENCE 700 1- Maunoury C. Service de Médecine Nucléaire, Hôpital Necker - Enfants Malades, 149 rue de Sèvres, 75 743 Paris Cedex 15, France, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer