caa a22 4500 475756231 CHVBK 20180406123538.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s002470050752 doi (NATIONALLICENCE)springer-10.1007/s002470050752 The use of oral pentobarbital sodium (Nembutal) versus oral chloral hydrate in infants undergoing CT and MR imaging - a pilot study [Elektronische Daten] [Taylor Chung, Fredric A. Hoffer, Linda Connor, David Zurakowski, P. E. Burrows] Background. Chloral hydrate, a commonly used oral sedative for infants undergoing imaging examinations, has a bitter taste and requires relatively large volume, provoking unpleasant reactions from the infants. Experience with an alternative sedative, oral pentobarbital (Nembutal), has not been reported for infants Objective. To compare patient acceptance of oral Nembutal and oral chloral hydrate for sedation of infants up to 12 months of age. Methods and materials. Fifty-four infants (mean age: 7 months) were prospectively enrolled. Parents chose Nembutal, chloral hydrate, or no preference. Thirty-eight infants received Nembutal (4-6 mg/kg) mixed with cherry syrup and 16 received chloral hydrate (50-100 mg/kg). We recorded infant's acceptance of sedative, parental impression of infant's acceptance, time to sedation, time to discharge, adverse effects, parental preference of future sedative. Results. Infant acceptance and parental impression were better for Nembutal (P < 0.0001). Fewer parents in the Nembutal group preferred another sedative (P = 0.05). There was a trend toward shorter time to discharge with Nembutal (P = 0.03). There were no adverse effects in either group. One infant failed to sedate with Nembutal. Conclusions. Compared with chloral hydrate, oral Nembutal has significantly better acceptance by infants and parents, equal effectiveness, and may result in a shorter time to discharge. Springer-Verlag Berlin Heidelberg, 2000 Chung Taylor Department of Radiology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA, US aut Hoffer Fredric A. Department of Radiology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA, US aut Connor Linda Department of Radiology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA, US aut Zurakowski David Research Computing, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA, US aut Burrows P. E. Department of Radiology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA, US aut https://doi.org/10.1007/s002470050752 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002470050752 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chung Taylor Department of Radiology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA, US aut NATIONALLICENCE 700 1- Hoffer Fredric A. Department of Radiology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA, US aut NATIONALLICENCE 700 1- Connor Linda Department of Radiology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA, US aut NATIONALLICENCE 700 1- Zurakowski David Research Computing, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA, US aut NATIONALLICENCE 700 1- Burrows P. E. Department of Radiology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer