caa a22 4500 475759419 CHVBK 20180406123546.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/BF02495168 doi (NATIONALLICENCE)springer-10.1007/BF02495168 Synthesis, structure, and biological activity of mixed-ligand platinum(II) complexes with aminonitroxides [Elektronische Daten] [V. Sen, N. Rukina, V. Tkachev, A. Pis'menskii, L. Volkova, S. Goncharova, T. Raevskaya, A. Tikhomirov, L. Gorbacheva, N. Konovalova] Mixed-ligand platinum complexescis-PtII(R6NH2)(NH3)X2 andcis-PtII(R5NH2)(NH3)X2 (R6 is 2,2,6,6-tetramethyl-4-piperidyl-1-oxyl and R5 is 2,2,5,5-tetramethyl-3-pyrrolidinyl-1-oxyl) were synthesized by either the reaction of aminonitroxides RNH2 with Na[PtII(NH3)Cl2I] generatedin situ (for X2=ClI) or by replacement of the iodo-chloro ligands incis-Pt11(RNH2)(NH3)ClI by dichloro and oxalato ligands. The complexes obtained were characterized by elemental analysis and by IR, UV, and ESR spectra. Forcis-Pt11(R5NH2)(NH3)Cl2, crystal and molecular structures were determined by X-ray diffraction analysis. Cisplatin accelerates autooxidation of methyl linoleate and the platinum nitroxide complexes synthesized exhibit antioxidant properties. The rate of isolated DNA binding with the new complexes is almost as high as that for cisplatin.cis-Pt11(R6NH2)(NH3)Cl2 exhibits the highest antitumor activity. The high antitumor activity of platinum nitroxide complexes shows that the possible "radical component” is not a crucial factor in the cytotoxic action of cisplatin. Kluwer Academic/Plenum Publishers, 2000 platinum(II) complexes nationallicence nitroxides nationallicence structure nationallicence antioxidants nationallicence antitumor activity nationallicence cytotoxicity nationallicence cisplatin nationallicence Sen V. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut Rukina N. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut Tkachev V. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut Pis'menskii A. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut Volkova L. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut Goncharova S. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut Raevskaya T. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut Tikhomirov A. N. M. Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 117997, Moscow, Russian Federation aut Gorbacheva L. N. M. Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 117997, Moscow, Russian Federation aut Konovalova N. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut Russian Chemical Bulletin Kluwer Academic Publishers-Plenum Publishers 49/9(2000-09-01), 1613-1619 1066-5285 49:9<1613 2000 49 11172 https://doi.org/10.1007/BF02495168 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02495168 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sen V. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut NATIONALLICENCE 700 1- Rukina N. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut NATIONALLICENCE 700 1- Tkachev V. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut NATIONALLICENCE 700 1- Pis'menskii A. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut NATIONALLICENCE 700 1- Volkova L. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut NATIONALLICENCE 700 1- Goncharova S. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut NATIONALLICENCE 700 1- Raevskaya T. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut NATIONALLICENCE 700 1- Tikhomirov A. N. M. Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 117997, Moscow, Russian Federation aut NATIONALLICENCE 700 1- Gorbacheva L. N. M. Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 117997, Moscow, Russian Federation aut NATIONALLICENCE 700 1- Konovalova N. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation aut NATIONALLICENCE 773 0- Russian Chemical Bulletin Kluwer Academic Publishers-Plenum Publishers 49/9(2000-09-01), 1613-1619 1066-5285 49:9<1613 2000 49 11172 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer