caa a22 4500 475762436 CHVBK 20180406123555.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1023/A:1009654728475 doi (NATIONALLICENCE)springer-10.1023/A:1009654728475 Dose-response relationships in mutagenicity assays including an appropriate positive control group: a multiple testing approach [Elektronische Daten] [Ludwig Hothorn, Makoto Hayashi, Dirk Seidel] The objective of mutagenicity assays in regulatory toxicology is the decision on non-mutagenicity or mutagenicity. An inherent problem of statistical tests is the possibility of false decisions, i.e., a mutagenic substance will be falsely labeled as non-mutagenic or a non-mutagenic substance will be falsely labeled as mutagenic. These probabilities of false negative (consumer's risk=type II error) and/or false positive decision (producer's risk=type I error) can be limited by using suitable testing procedures as well as a design including an appropriate positive control. Using the proof of hazard concept the well-known many-to-one procedures with total order restriction for increasing effect differences are used, while using the proof of safety concept procedures on equivalence with total order restriction are discussed. Both approaches are demonstrated on a real data example. Kluwer Academic Publishers, 2000 dose-response analysis nationallicence positive control nationallicence mutagenicity studies nationallicence Hothorn Ludwig Department of Bioinformatics, University of Hannover, Herrenhauser Str. 2, D-30419, Hannover, Germany aut Hayashi Makoto National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, 158, Tokyo, Japan aut Seidel Dirk Department of Bioinformatics, University of Hannover, Herrenhauser Str. 2, D-30419, Hannover, Germany aut Environmental and Ecological Statistics Kluwer Academic Publishers 7/1(2000-03-01), 27-42 1352-8505 7:1<27 2000 7 10651 https://doi.org/10.1023/A:1009654728475 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1009654728475 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hothorn Ludwig Department of Bioinformatics, University of Hannover, Herrenhauser Str. 2, D-30419, Hannover, Germany aut NATIONALLICENCE 700 1- Hayashi Makoto National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, 158, Tokyo, Japan aut NATIONALLICENCE 700 1- Seidel Dirk Department of Bioinformatics, University of Hannover, Herrenhauser Str. 2, D-30419, Hannover, Germany aut NATIONALLICENCE 773 0- Environmental and Ecological Statistics Kluwer Academic Publishers 7/1(2000-03-01), 27-42 1352-8505 7:1<27 2000 7 10651 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer