caa a22 4500 475762614 CHVBK 20180406123555.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1009615027279 doi (NATIONALLICENCE)springer-10.1023/A:1009615027279 Modified Weibull multi-state models for the analysis of animal carcinogenicity data [Elektronische Daten] [Nigel Stallard, Anne Whitehead] The Peto test is the standard method of analysis used in carcinogenicity studies to compare tumor incidence in groups of animals. It assumes that tumors are either instantly fatal or have no effect on mortality and requires a judgement of the lethality of each tumor. To avoid this requirement, parametric multi-state models have been proposed. In addition these allow estimation of tumor onset and mortality rates. This paper considers two such models and presents a modification. It is shown that the modified models provide a better fit to carcinogenicity data and simulated data are used to show that the modified models provide a modest increase in test power relative to the Peto test. Kluwer Academic Publishers, 2000 Peto test nationallicence survival/sacrifice experiments nationallicence tumor data simulation nationallicence Stallard Nigel Medical and Pharmaceutical Statistics Research Unit, The University of Reading, Earley Gate, PO Box 240, RG6 6FN, Reading, Berkshire, UK aut Whitehead Anne Medical and Pharmaceutical Statistics Research Unit, The University of Reading, Earley Gate, PO Box 240, RG6 6FN, Reading, Berkshire, UK aut Environmental and Ecological Statistics Kluwer Academic Publishers 7/2(2000-06-01), 117-133 1352-8505 7:2<117 2000 7 10651 https://doi.org/10.1023/A:1009615027279 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1009615027279 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stallard Nigel Medical and Pharmaceutical Statistics Research Unit, The University of Reading, Earley Gate, PO Box 240, RG6 6FN, Reading, Berkshire, UK aut NATIONALLICENCE 700 1- Whitehead Anne Medical and Pharmaceutical Statistics Research Unit, The University of Reading, Earley Gate, PO Box 240, RG6 6FN, Reading, Berkshire, UK aut NATIONALLICENCE 773 0- Environmental and Ecological Statistics Kluwer Academic Publishers 7/2(2000-06-01), 117-133 1352-8505 7:2<117 2000 7 10651 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer