caa a22 4500 475762649 CHVBK 20180406123555.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1009683114075 doi (NATIONALLICENCE)springer-10.1023/A:1009683114075 Dose-response modeling for developmental neurotoxicity data [Elektronische Daten] [Mehdi Razzaghi, Ralph Kodell] The fact that maternal exposures to some chemicals during pregnancy can adversely affect the structure and function of the nervous system in the offspring is well established. Government agencies have for a long time been concerned with regulation of developmental neurotoxicants and safe perinatal exposures. However, despite this concern, current guidelines provide only broad and nonspecific recommendations and lack clear directions for a model based approach to risk estimation. In this paper we propose a dose-response model for the nonquantal data obtained from developmental neurotoxicological experiments. To account for the critical issue of the correlation among responses from pups in the same litter, the so called intralitter correlation, a hierarchical distributional structure is used to derive the underlying unconditional distribution of responses. The maximum likelihood method is used to estimate model parameters and the covariance matrix of the estimates is derived. An example is used to illustrate the results. Kluwer Academic Publishers, 2000 intralitter correlation nationallicence maximum likelihood nationallicence neurotoxic effect nationallicence nonquantal data nationallicence Razzaghi Mehdi Bloomsburg University, PA, USA aut Kodell Ralph National Center for Toxicological Research (NCTR), US Food and Drug Administration (FDA), Jefferson, AR, USA aut Environmental and Ecological Statistics Kluwer Academic Publishers 7/2(2000-06-01), 191-203 1352-8505 7:2<191 2000 7 10651 https://doi.org/10.1023/A:1009683114075 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1009683114075 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Razzaghi Mehdi Bloomsburg University, PA, USA aut NATIONALLICENCE 700 1- Kodell Ralph National Center for Toxicological Research (NCTR), US Food and Drug Administration (FDA), Jefferson, AR, USA aut NATIONALLICENCE 773 0- Environmental and Ecological Statistics Kluwer Academic Publishers 7/2(2000-06-01), 191-203 1352-8505 7:2<191 2000 7 10651 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer