caa a22 4500 475762886 CHVBK 20180406123556.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s005800070017 doi (NATIONALLICENCE)springer-10.1007/s005800070017 Analysis of Cell-Mediated Cytotoxicity of CD18-Deficient Bovine Neutrophils [Elektronische Daten] [H. Nagahata, H. Higuchi, M. Kasamatsu] Abstract:: Killing activity (KA) and antibody-dependent cell cytotoxicity (ADCC) of neutrophils from normal cattle and cattle with bovine leucocyte adhesion deficiency (BLAD) were compared in order to evaluate the cytotoxicity of CD18-deficient bovine neutrophils. The killing activity of CD18-deficient neutrophils was significantly lowered (p<0.01) when compared to normal neutrophils, whereas ADCC activity was increased. Fc receptor for immunoglobulin G (FcyR-IgG) mediated ADCC of neutrophils appeared to be enhanced in BLAD-neutrophils. Springer-Verlag London Limited, 2000 Key words: BLAD nationallicence (Bovine) neutrophils nationallicence CD18-deficiency nationallicence Cell cytotoxicity nationallicence Nagahata H. Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan, JP aut Higuchi H. Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan, JP aut Kasamatsu M. Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan, JP aut https://doi.org/10.1007/s005800070017 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005800070017 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nagahata H. Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan, JP aut NATIONALLICENCE 700 1- Higuchi H. Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan, JP aut NATIONALLICENCE 700 1- Kasamatsu M. Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer