caa a22 4500 475762908 CHVBK 20180406123556.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s005800070012 doi (NATIONALLICENCE)springer-10.1007/s005800070012 Prediction of Distributions of Amino Acids and Amino Acid Pairs in Human Haemoglobin α-Chain and its Seven Variants Causing α-Thalassaemia from their Occurrences According to the Random Mechanism [Elektronische Daten] [G. Wu, S.-M. Yan] Abstract:: The probabilities of distributions of amino acids and amino acid pairs in normal human haemoglobin α-chain and its seven variants causing α-thalassaemia were studied to elicit the randomness of their positioning. The results show that 47.37% of distributions of amino acids conform to a simple random distribution and the distributions of the remaining amino acids are very near to a simple random distribution. However, variants of these patterns lead to nine distribution probabilities to increase and thus to occur more often, one distribution probability slightly decreases but its rank with respect to its distribution probability is unchanged and four distribution probabilities to decrease and thus occur less often among 14 distribution probabilities there being the least random in occurence. The decreased distribution probabilities in variants are exclusively related to leucine. Springer-Verlag London Limited, 2000 Key words: Amino acids nationallicence Haemoglobin nationallicence Prediction nationallicence α-Thalassaemia nationallicence Wu G. Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, Université de la Méditerranée Aix-Marseille II, Marseille, France, FR aut Yan S.-M Cattedra di Anatomia Patologica, Dipartimento di Ricerche Mediche e Morfologiche, Facoltà di Medicina e Chirurgia, Università degli Studi di Udine, Udine, Italy, IT aut https://doi.org/10.1007/s005800070012 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s005800070012 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu G. Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, Université de la Méditerranée Aix-Marseille II, Marseille, France, FR aut NATIONALLICENCE 700 1- Yan S.-M Cattedra di Anatomia Patologica, Dipartimento di Ricerche Mediche e Morfologiche, Facoltà di Medicina e Chirurgia, Università degli Studi di Udine, Udine, Italy, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer