caa a22 4500 475763858 CHVBK 20180406123559.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s003960000331 doi (NATIONALLICENCE)springer-10.1007/s003960000331 The temperature dependence of the micellisation of chlorpromazine hydrochloride in aqueous solution [Elektronische Daten] [M. Pérez-Rodríguez, L. M. Varela, P. Taboada, D. Attwood, V. Mosquera] The association characteristics of the weakly associating drug chlorpromazine hydrochloride have been examined over the temperature range 10-35 °C by means of conductimetric measurements. Critical micelle concentrations (cmc) have been determined by the application of a recently developed numerical method [Pérez-Rodríguez et al. (1998) Langmuir 14:4422] especially designed for the analysis of the association pattern in highly polydisperse systems of low aggregation number. The cmcs determined in this manner are used in combination with the mass-action model to obtain the thermodynamic parameters of the micellisation process, in particular the surface and hydrophobic contributions to the free energy. The use of exact forms of equations for the thermodynamics of micellisation applicable to systems of low aggregation number leads to values of the enthalpy of micellisation in reasonable agreement with experimentally determined values. Springer-Verlag Berlin Heidelberg, 2000 Key words Thermodynamics of micellisation nationallicence Critical micelle concentrations nationallicence Drugs nationallicence Chlorpromazine hydrochloride nationallicence Micelles nationallicence Pérez-Rodríguez M. Grupo de Física de Coloides y Polímeros Departamento de Física de la Materia Condensada, Universidad de Santiago de Compostela, 15706 Santiago, Spain e-mail: fmvictor@usc.es, ES aut Varela L. M. Grupo de Física de Coloides y Polímeros Departamento de Física de la Materia Condensada, Universidad de Santiago de Compostela, 15706 Santiago, Spain e-mail: fmvictor@usc.es, ES aut Taboada P. Grupo de Física de Coloides y Polímeros Departamento de Física de la Materia Condensada, Universidad de Santiago de Compostela, 15706 Santiago, Spain e-mail: fmvictor@usc.es, ES aut Attwood D. School of Pharmacy and Pharmaceutical Sciences, University of Manchester Manchester M13 9PL, UK, GB aut Mosquera V. Grupo de Física de Coloides y Polímeros Departamento de Física de la Materia Condensada, Universidad de Santiago de Compostela, 15706 Santiago, Spain e-mail: fmvictor@usc.es, ES aut https://doi.org/10.1007/s003960000331 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s003960000331 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pérez-Rodríguez M. Grupo de Física de Coloides y Polímeros Departamento de Física de la Materia Condensada, Universidad de Santiago de Compostela, 15706 Santiago, Spain e-mail: fmvictor@usc.es, ES aut NATIONALLICENCE 700 1- Varela L. M. Grupo de Física de Coloides y Polímeros Departamento de Física de la Materia Condensada, Universidad de Santiago de Compostela, 15706 Santiago, Spain e-mail: fmvictor@usc.es, ES aut NATIONALLICENCE 700 1- Taboada P. Grupo de Física de Coloides y Polímeros Departamento de Física de la Materia Condensada, Universidad de Santiago de Compostela, 15706 Santiago, Spain e-mail: fmvictor@usc.es, ES aut NATIONALLICENCE 700 1- Attwood D. School of Pharmacy and Pharmaceutical Sciences, University of Manchester Manchester M13 9PL, UK, GB aut NATIONALLICENCE 700 1- Mosquera V. Grupo de Física de Coloides y Polímeros Departamento de Física de la Materia Condensada, Universidad de Santiago de Compostela, 15706 Santiago, Spain e-mail: fmvictor@usc.es, ES aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer