caa a22 4500 475763955 CHVBK 20180406123559.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s003960000292 doi (NATIONALLICENCE)springer-10.1007/s003960000292 Influence of cellulose type on the properties of extruded pellets. Part I. Physicochemical characterisation of the cellulose types after homogenisation [Elektronische Daten] [M. Jumaa, F. El Saleh, I. Hassan, B. W. Müller, P. Kleinebudde]  The physicochemical properties of different types of powdered cellulose (PC) and microcrystalline cellulose (MCC) were studied by examining the changes in particle size, viscosity and specific surface area after a homogenisation process. An additional characterisation was carried out using X-ray diffractometry. A preliminary investigation using a type of MCC showed that increasing the homogenisation pressure and the number of passage cycles led to a significant decrease in the particle size and simultaneously to a remarkable increase in the specific surface area and viscosity. Most MCC types showed the same pattern during the homogenisation process. "Colloidal” MCC displayed a higher viscosity than the others but without significant change in the viscosity after different homogenisation cycles. In contrast to this behaviour of the MCCs, the PCs showed no remarkable change in the particle size but did show a marked change in their viscosity. Furthermore, only MCC suspensions, with the exception of "colloidal” MCC, agglomerated after the homogenisation process, whereas this was not seen in the PC suspensions. Hence, since the MCC types as well as the PC types originally had the same chemical structure, this different behaviour among these types can only be attributed to their different physical properties. Springer-Verlag Berlin Heidelberg, 2000 Key words Powdered cellulose nationallicence Microcrystalline cellulose nationallicence Physicochemical properties nationallicence Homogenisation process nationallicence Jumaa M. Department of Pharmaceutics & Biopharmaceutics, Christian Albrecht University Kiel Kiel, Germany, DE aut El Saleh F. Department of Pharmaceutics & Biopharmaceutics, Christian Albrecht University Kiel Kiel, Germany, DE aut Hassan I. Department of Pharmaceutics & Biopharmaceutics, Damascus University Damascus, Syria, SY aut Müller B. W. Department of Pharmaceutics & Biopharmaceutics, Christian Albrecht University Kiel Kiel, Germany, DE aut Kleinebudde P. Institute of Pharmaceutics & Biopharmaceutics Martin Luther University, Halle-Wittenberg Wolfgang-Langenbeck-Strasse 4 06120 Halle, Germany e-mail: kleinebudde@pharmazie.uni-halle.de Tel.: +49-345-5525167 Fax: +49-345-5527029, DE aut https://doi.org/10.1007/s003960000292 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s003960000292 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jumaa M. Department of Pharmaceutics & Biopharmaceutics, Christian Albrecht University Kiel Kiel, Germany, DE aut NATIONALLICENCE 700 1- El Saleh F. Department of Pharmaceutics & Biopharmaceutics, Christian Albrecht University Kiel Kiel, Germany, DE aut NATIONALLICENCE 700 1- Hassan I. Department of Pharmaceutics & Biopharmaceutics, Damascus University Damascus, Syria, SY aut NATIONALLICENCE 700 1- Müller B. W. Department of Pharmaceutics & Biopharmaceutics, Christian Albrecht University Kiel Kiel, Germany, DE aut NATIONALLICENCE 700 1- Kleinebudde P. Institute of Pharmaceutics & Biopharmaceutics Martin Luther University, Halle-Wittenberg Wolfgang-Langenbeck-Strasse 4 06120 Halle, Germany e-mail: kleinebudde@pharmazie.uni-halle.de Tel.: +49-345-5525167 Fax: +49-345-5527029, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer