caa a22 4500 475764099 CHVBK 20180406123559.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s003960000389 doi (NATIONALLICENCE)springer-10.1007/s003960000389 Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin [Elektronische Daten] [K. Y. Lee, J.-H. Kim, I. C. Kwon, S. Y. Jeong] A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering, fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregates, suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2). Springer-Verlag Berlin Heidelberg, 2000 Key words Chitosan nationallicence Deoxycholic acid nationallicence Self-aggregate nationallicence Nanoparticle nationallicence Adriamycin nationallicence Lee K. Y. Biomedical Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea e-mail: syjeong@kistmail.kist.re.kr Tel.: +82-2958-5911 Fax: +82-2958-5909, KR aut Kim J.-H Biomedical Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea e-mail: syjeong@kistmail.kist.re.kr Tel.: +82-2958-5911 Fax: +82-2958-5909, KR aut Kwon I. C. Biomedical Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea e-mail: syjeong@kistmail.kist.re.kr Tel.: +82-2958-5911 Fax: +82-2958-5909, KR aut Jeong S. Y. Biomedical Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea e-mail: syjeong@kistmail.kist.re.kr Tel.: +82-2958-5911 Fax: +82-2958-5909, KR aut https://doi.org/10.1007/s003960000389 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s003960000389 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee K. Y. Biomedical Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea e-mail: syjeong@kistmail.kist.re.kr Tel.: +82-2958-5911 Fax: +82-2958-5909, KR aut NATIONALLICENCE 700 1- Kim J.-H Biomedical Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea e-mail: syjeong@kistmail.kist.re.kr Tel.: +82-2958-5911 Fax: +82-2958-5909, KR aut NATIONALLICENCE 700 1- Kwon I. C. Biomedical Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea e-mail: syjeong@kistmail.kist.re.kr Tel.: +82-2958-5911 Fax: +82-2958-5909, KR aut NATIONALLICENCE 700 1- Jeong S. Y. Biomedical Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea e-mail: syjeong@kistmail.kist.re.kr Tel.: +82-2958-5911 Fax: +82-2958-5909, KR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer