caa a22 4500 475765516 CHVBK 20180406123604.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s007050050010 doi (NATIONALLICENCE)springer-10.1007/s007050050010 Neuron-glia interactions in the rat retina infected by Borna disease virus [Elektronische Daten] [J. Kacza, T. W. Vahlenkamp, H. Enbergs, J. A. Richt, A. Germer, H. Kuhrt, A. Reichenbach, H. Müller, C. Herden, T. Stahl, J. Seeger] Summary.:  Neuron-glia interactions in the Borna disease virus (BDV)-infected rat retina were investigated with emphasis on the ultrastructural characterization of degenerative alterations in the ganglion cell and photoreceptor layer. Immuno- and cytochemical techniques were applied to label microglia, macrophages and Müller (macroglial) cells. Four weeks after intracerebral infection of adult rats, the total thickness of the retina was considerably diminished, primarily due to the loss of photoreceptor segments and ganglion cells. A gradual reduction of both plexiform layers was also observed. There was a remarkable increase in the number of microglial cells, predominantly in the ganglion cell and the inner plexiform layers. Ultrastructural analysis confirmed that microglia, but also macrophages, were involved in phagocytosis accompanying severe neuronal degeneration in the ganglion cell and the photoreceptor layer. In contrast, Müller cells showed moderate morphological and cytochemical alterations, indicating that Müller cells play only a minor role in early stages of BDV-induced retinitis. Monitoring neuron-glia interactions in BDV-induced retinopathy, combined with the application of different protocols of immunosuppression effecting the BDV virus and/or the microglia, might help to establish specific strategies to suppress BDV-induced neuronal degeneration. 2000 Springer-Verlag/, Wien Kacza J. Institute of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut Vahlenkamp T. W. Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut Enbergs H. Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut Richt J. A. Institute of Virology, Justus-Liebig University Giessen, Giessen, Germany, DE aut Germer A. Paul-Flechsig-Institute for Brain Research, Department of Neurophysiology, Faculty of Medicine, University of Leipzig, Leipzig, Germany, DE aut Kuhrt H. Paul-Flechsig-Institute for Brain Research, Department of Neurophysiology, Faculty of Medicine, University of Leipzig, Leipzig, Germany, DE aut Reichenbach A. Paul-Flechsig-Institute for Brain Research, Department of Neurophysiology, Faculty of Medicine, University of Leipzig, Leipzig, Germany, DE aut Müller H. Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut Herden C. Institute of Virology, Justus-Liebig University Giessen, Giessen, Germany, DE aut Stahl T. Institute of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut Seeger J. Institute of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut https://doi.org/10.1007/s007050050010 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050050010 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kacza J. Institute of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut NATIONALLICENCE 700 1- Vahlenkamp T. W. Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut NATIONALLICENCE 700 1- Enbergs H. Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut NATIONALLICENCE 700 1- Richt J. A. Institute of Virology, Justus-Liebig University Giessen, Giessen, Germany, DE aut NATIONALLICENCE 700 1- Germer A. Paul-Flechsig-Institute for Brain Research, Department of Neurophysiology, Faculty of Medicine, University of Leipzig, Leipzig, Germany, DE aut NATIONALLICENCE 700 1- Kuhrt H. Paul-Flechsig-Institute for Brain Research, Department of Neurophysiology, Faculty of Medicine, University of Leipzig, Leipzig, Germany, DE aut NATIONALLICENCE 700 1- Reichenbach A. Paul-Flechsig-Institute for Brain Research, Department of Neurophysiology, Faculty of Medicine, University of Leipzig, Leipzig, Germany, DE aut NATIONALLICENCE 700 1- Müller H. Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut NATIONALLICENCE 700 1- Herden C. Institute of Virology, Justus-Liebig University Giessen, Giessen, Germany, DE aut NATIONALLICENCE 700 1- Stahl T. Institute of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut NATIONALLICENCE 700 1- Seeger J. Institute of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer