caa a22 4500 475765621 CHVBK 20180406123604.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s007050050016 doi (NATIONALLICENCE)springer-10.1007/s007050050016 Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve [Elektronische Daten] [K. Shinya, A. Shimada, T. Ito, K. Otsuki, T. Morita, H. Tanaka, A. Takada, H. Kida, T. Umemura] Summary.:  To define the route of influenza virus invasion into the central nervous system (CNS), an avian influenza A (H5N3) virus was inoculated into mice intranasally or intravenously. Only the intranasal infection group mice showed depression and retention of gas in the digestive system. Pathological findings in the animals were bronchointerstitial pneumonia and non-suppurative encephalitis restricted to the brain stem. The nerve nucleus primarily affected was the nucleus of solitary tract. Prior to the development of the CNS lesions, viral antigen was detected in vagal and trigeminal ganglia. These results suggest that the primarily replicated virus in the respiratory mucosa ascended to the CNS via sensory nerve routes, inducing lesions in the brain stem, and then spread trans-synaptically in the CNS. 2000 Springer-Verlag/, Wien Shinya K. Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut Shimada A. Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut Ito T. Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut Otsuki K. Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut Morita T. Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut Tanaka H. Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Takada A. Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Kida H. Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Umemura T. Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut https://doi.org/10.1007/s007050050016 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050050016 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shinya K. Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut NATIONALLICENCE 700 1- Shimada A. Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut NATIONALLICENCE 700 1- Ito T. Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut NATIONALLICENCE 700 1- Otsuki K. Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut NATIONALLICENCE 700 1- Morita T. Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut NATIONALLICENCE 700 1- Tanaka H. Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Takada A. Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Kida H. Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Umemura T. Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer