caa a22 4500 475765753 CHVBK 20180406123605.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s007050070109 doi (NATIONALLICENCE)springer-10.1007/s007050070109 Cross-protection and reassortment studies with avian H2 influenza viruses [Elektronische Daten] [N. V. Kaverin, Y. A. Smirnov, E. A. Govorkova, I. A. Rudneva, A. K. Gitelman, A. S. Lipatov, N. L. Varich, S. S. Yamnikova, N. V. Makarova, R. G. Webster, D. K. Lvov] Summary.:  In order to assess the degree of immune cross-protection among avian H2 influenza virus strains, mice were immunised with β-propiolactone-inactivated virus preparations and infected intranasally with mouse-adapted variant of A/Black Duck/New Jersey/1580/78 (H2N3) strain. The experiments with 11 avian H2 strains revealed that both Eurasian and American H2 avian influenza viruses exhibit either high or moderate degree of cross-protection. The grouping of the strains in accordance with their cross-protection efficiency does not coincide with H2 phylogenetic branches. Several reassortant clones were obtained with the use of A/Pintail Duck/Primorie/695/76 (H2N3) strain and high-yield X-67 reassortant as parent viruses, among them a high-yield H2N3 reassortant. Taking into account the data on cross-protection among avian H2 strains, the high-yield H2N3 reassortant may be regarded as a prototype strain to be used for the preparation of killed vaccines in the case of a new appearance of avian H2 haemagglutinin in circulation in humans. Springer-Verlag/Wien, 2000 Kaverin N. V. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut Smirnov Y. A. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut Govorkova E. A. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut Rudneva I. A. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut Gitelman A. K. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut Lipatov A. S. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut Varich N. L. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut Yamnikova S. S. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut Makarova N. V. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut Webster R. G. Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, U.S.A., US aut Lvov D. K. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut https://doi.org/10.1007/s007050070109 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050070109 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaverin N. V. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Smirnov Y. A. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Govorkova E. A. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Rudneva I. A. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Gitelman A. K. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Lipatov A. S. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Varich N. L. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Yamnikova S. S. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Makarova N. V. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Webster R. G. Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, U.S.A., US aut NATIONALLICENCE 700 1- Lvov D. K. The D. I. Ivanovsky Institute of Virology RAMS, Moscow, Russia, RU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer