caa a22 4500 475765877 CHVBK 20180406123605.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s007050070065 doi (NATIONALLICENCE)springer-10.1007/s007050070065 Hepatitis E virus infection in chimpanzees: a retrospective analysis [Elektronische Daten] [K. A. McCaustland, K. Krawczynski, J. W. Ebert, M. S. Balayan, A. G. Andjaparidze, J. E. Spelbring, E. H. Cook, C. Humphrey, P. O. Yarbough, M. O. Favorov, D. Carson, D. W. Bradley, B. H. Robertson] Summary.:  Different patterns of disease were observed among 11 chimpanzees who were inoculated intravenously with hepatitis E virus (HEV) positive fecal specimens from four different outbreaks (Nepal 1981, Uzbekistan 1981, Pakistan 1985, and Mexico 1986). Five chimpanzees had marginal or no liver enzyme elevations within 70 days of inoculation. Two of the chimpanzees had limited viremia, but did not produce detectable antibody. The four remaining chimpanzees had liver enzyme elevations, viral shedding, viremia, seroconversion to anti-HEV, and detectable HEV antigen in liver biopsy specimens. These results may reflect the range of infection patterns that develop in humans after natural exposure to the HEV. Springer-Verlag/Wien, 2000 McCaustland K. A. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut Krawczynski K. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut Ebert J. W. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut Balayan M. S. Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia, RU aut Andjaparidze A. G. Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia, RU aut Spelbring J. E. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut Cook E. H. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut Humphrey C. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut Yarbough P. O. Genelabs Inc, Redwood City, California, U.S.A., US aut Favorov M. O. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut Carson D. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut Bradley D. W. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut Robertson B. H. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut Archives of Virology Springer-Verlag 145/9(2000-09-01), 1909-1918 0304-8608 145:9<1909 2000 145 705 https://doi.org/10.1007/s007050070065 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050070065 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McCaustland K. A. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut NATIONALLICENCE 700 1- Krawczynski K. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut NATIONALLICENCE 700 1- Ebert J. W. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut NATIONALLICENCE 700 1- Balayan M. S. Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Andjaparidze A. G. Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Spelbring J. E. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut NATIONALLICENCE 700 1- Cook E. H. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut NATIONALLICENCE 700 1- Humphrey C. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut NATIONALLICENCE 700 1- Yarbough P. O. Genelabs Inc, Redwood City, California, U.S.A., US aut NATIONALLICENCE 700 1- Favorov M. O. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut NATIONALLICENCE 700 1- Carson D. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut NATIONALLICENCE 700 1- Bradley D. W. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut NATIONALLICENCE 700 1- Robertson B. H. Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, U.S.A., GE aut NATIONALLICENCE 773 0- Archives of Virology Springer-Verlag 145/9(2000-09-01), 1909-1918 0304-8608 145:9<1909 2000 145 705 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer