caa a22 4500 475766326 CHVBK 20180406123606.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s007050070011 doi (NATIONALLICENCE)springer-10.1007/s007050070011 Equine herpesvirus 9 induced lethal encephalomyelitis in experimentally infected goats [Elektronische Daten] [A. Taniguchi, H. Fukushi, T. Yanai, T. Masegi, T. Yamaguchi, K. Hirai] Summary.:  The pathogenicity of a new neurotropic equine herpesvirus 9 (EHV-9) formerly designated gazelle herpesvirus 1 was evaluated using the goat as a representative of domesticated ruminants. Two goats inoculated intranasally with EHV-9 showed salivation, teeth grinding and other neurological disorders on day 8 post inoculation. One goat died 30 min after the onset of clinical signs and the other was sacrificed 3 h after the sudden onset of teeth grinding and foamy salivation. EHV-9 was recovered from peripheral white blood cells, the olfactory bulbs and brain, nasal swabs, concha, and lungs. Neuropathological lesions were located in the olfactory bulbs, cerebrum, midbrain and medulla oblongata with degeneration and necrosis of neurons, rarefaction, perivascular infiltration of mononuclear cells, and nodal glial reaction. EHV-9 antigen was detected in neurons in the lesions. These findings indicated that EHV-9 is highly pathogenic with high neurotropism for goats. Springer-Verlag/Wien, 2000 Taniguchi A. Department of Veterinary Pathology, Gifu University, Gifu, Japan, JP aut Fukushi H. Department of Veterinary Microbiology, Faculty of Agriculture, Gifu University, Gifu, Japan, JP aut Yanai T. Department of Veterinary Pathology, Gifu University, Gifu, Japan, JP aut Masegi T. Department of Veterinary Pathology, Gifu University, Gifu, Japan, JP aut Yamaguchi T. Department of Veterinary Microbiology, Faculty of Agriculture, Gifu University, Gifu, Japan, JP aut Hirai K. Department of Veterinary Microbiology, Faculty of Agriculture, Gifu University, Gifu, Japan, JP aut https://doi.org/10.1007/s007050070011 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050070011 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Taniguchi A. Department of Veterinary Pathology, Gifu University, Gifu, Japan, JP aut NATIONALLICENCE 700 1- Fukushi H. Department of Veterinary Microbiology, Faculty of Agriculture, Gifu University, Gifu, Japan, JP aut NATIONALLICENCE 700 1- Yanai T. Department of Veterinary Pathology, Gifu University, Gifu, Japan, JP aut NATIONALLICENCE 700 1- Masegi T. Department of Veterinary Pathology, Gifu University, Gifu, Japan, JP aut NATIONALLICENCE 700 1- Yamaguchi T. Department of Veterinary Microbiology, Faculty of Agriculture, Gifu University, Gifu, Japan, JP aut NATIONALLICENCE 700 1- Hirai K. Department of Veterinary Microbiology, Faculty of Agriculture, Gifu University, Gifu, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer