caa a22 4500 475766334 CHVBK 20180406123606.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s007050070010 doi (NATIONALLICENCE)springer-10.1007/s007050070010 Immune responses and cytokine induction in the development of severe hepatitis during acute infections with murine cytomegalovirus [Elektronische Daten] [J. Trgovcich, D. Štimac, B. Polić, A. Krmpotić, E. Pernjak-Pugel, J. Tomac, M. Hasan, B. Wraber, S. Jonjić] Summary.:  Salivary gland-derived murine cytomegalovirus (SGV) infections of mice have been widely used as models of human cytomegalovirus infections and in the study of CMV biology. Still, many aspects of SGV pathogenesis are not clearly defined. Fatal and non-fatal SGV infections were investigated to characterize pathogenetic correlates of mortality and to assess the role of the immune response in disease progression. Suppression of immune responses was observed in both lethal and sublethal infections. Depletion of immune cell populations in spleen, however, correlated with severe CMV-induced hepatitis and mortality. In addition, T cell depletion studies indicated a requirement for this immune cell subset in control of liver damage and survival of infected mice. Examination of cytokine responses revealed a previously undescribed shock-like syndrome in lethally-infected mice characterized by high levels of tumor necrosis factor α and interferon γ. Furthermore, the sites of tumor necrosis factor α gene induction did not strictly correlate with either viral load or the sites of tissue damage during infection. Taken together, these findings define the pathogenetic progression of disease as it relates to disease outcome and suggests that organ-specific differences in cytokine induction play a significant role in the late stages of acute lethal MCMV infections. Springer-Verlag/Wien, 2000 Trgovcich J. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut Štimac D. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut Polić B. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut Krmpotić A. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut Pernjak-Pugel E. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut Tomac J. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut Hasan M. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut Wraber B. Institute of Microbiology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia aut Jonjić S. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut https://doi.org/10.1007/s007050070010 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050070010 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Trgovcich J. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut NATIONALLICENCE 700 1- Štimac D. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut NATIONALLICENCE 700 1- Polić B. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut NATIONALLICENCE 700 1- Krmpotić A. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut NATIONALLICENCE 700 1- Pernjak-Pugel E. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut NATIONALLICENCE 700 1- Tomac J. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut NATIONALLICENCE 700 1- Hasan M. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut NATIONALLICENCE 700 1- Wraber B. Institute of Microbiology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Jonjić S. Department of Histology and Embryology, Medical Faculty, University of Rijeka, Rijeka, Croatia aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer