caa a22 4500 475766377 CHVBK 20180406123606.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s007050050041 doi (NATIONALLICENCE)springer-10.1007/s007050050041 Inhibitory activity of the human papillomavirus type 1 AU-rich element correlates inversely with the levels of the elav-like HuR protein in the cell cytoplasm [Elektronische Daten] [A. Carlsson, S. Schwartz] Summary.:  We have analysed the activity of the negative element in the late 3′ untranslated region of the cutaneous human papillomavirus type 1 (HPV-1) mRNAs in a panel of epithelial cells, of both mucosal and cutaneous origin. The inhibitory activity was cell line dependent. Determination of the levels of heterogeneous ribonucleoprotein C1/C2 and HuR that have been shown previously to interact specifically with the HPV-1 negative RNA element revealed that low levels of the HuR protein in the cytoplasmic fraction correlated with high inhibitory activity of the HPV-1 element, whereas cell lines displaying low inhibitory activity contained high levels of HuR in the cytoplasm. These results suggested that the HuR protein has a positive effect on HPV-1 late gene expression. 2000 Springer-Verlag/, Wien Carlsson A. Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden, SE aut Schwartz S. Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden, SE aut https://doi.org/10.1007/s007050050041 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050050041 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carlsson A. Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden, SE aut NATIONALLICENCE 700 1- Schwartz S. Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden, SE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer