caa a22 4500 475766415 CHVBK 20180406123607.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s007050050044 doi (NATIONALLICENCE)springer-10.1007/s007050050044 High frequency of postnatal transmission of TT virus in infancy [Elektronische Daten] [A. Kazi, H. Miyata, K. Kurokawa, M. A. Khan, T. Kamahora, S. Katamine, S. Hino] Abstract.:  DNA of TT virus (TTV), a novel human circovirus, was tested for in 116 mother-infant pairs who had participated in the adult T-cell leukemia prevention program (APP) in Nagasaki, Japan, and refrained from breast-feeding. By polymerase chain reaction with Okamoto's seminested primers, 36 of the 115 (31%) mothers were positive. At the age of 6-8 months, 7 of 29 (24%) and 6 of 72 (8%) infants born to infected and uninfected mothers were positive, respectively (P = 0.047; RR, 2.90). Maternal TTV DNA load did not correlate with infantile infections. Since 99 of 100 (99%) cord blood samples were negative and all the mothers refrained from breast-feeding, the infantile TTV transmission would not be intrauterine or milk-borne. Between 6-8 and 12-21 months of age, 4 of 12 (33%) and 5 of 22 (23%) children born to infected and uninfected mothers turned positive, respectively (NS). At 12-21 months of age, 8 of 21 (38%) and 12 of 32 (38%) children born to infected and uninfected mothers were positive, respectively (NS). These results indicate that the TTV infection prevails in children at a frequency comparative to that in their mothers within the first 2 years of life, regardless of the maternal TTV status. 2000 Springer-Verlag/, Wien Kazi A. Department of Virology, Faculty of Medicine, Tottori University, Yonago, Japan, JP aut Miyata H. Department of Virology, Faculty of Medicine, Tottori University, Yonago, Japan, JP aut Kurokawa K. Department of Bacteriology, School of Medicine, Nagasaki University, Nagasaki, Japan, JP aut Khan M. A. Department of Virology, Faculty of Medicine, Tottori University, Yonago, Japan, JP aut Kamahora T. Department of Virology, Faculty of Medicine, Tottori University, Yonago, Japan, JP aut Katamine S. Department of Bacteriology, School of Medicine, Nagasaki University, Nagasaki, Japan, JP aut Hino S. Department of Virology, Faculty of Medicine, Tottori University, Yonago, Japan, JP aut https://doi.org/10.1007/s007050050044 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050050044 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kazi A. Department of Virology, Faculty of Medicine, Tottori University, Yonago, Japan, JP aut NATIONALLICENCE 700 1- Miyata H. Department of Virology, Faculty of Medicine, Tottori University, Yonago, Japan, JP aut NATIONALLICENCE 700 1- Kurokawa K. Department of Bacteriology, School of Medicine, Nagasaki University, Nagasaki, Japan, JP aut NATIONALLICENCE 700 1- Khan M. A. Department of Virology, Faculty of Medicine, Tottori University, Yonago, Japan, JP aut NATIONALLICENCE 700 1- Kamahora T. Department of Virology, Faculty of Medicine, Tottori University, Yonago, Japan, JP aut NATIONALLICENCE 700 1- Katamine S. Department of Bacteriology, School of Medicine, Nagasaki University, Nagasaki, Japan, JP aut NATIONALLICENCE 700 1- Hino S. Department of Virology, Faculty of Medicine, Tottori University, Yonago, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer