caa a22 4500 475766520 CHVBK 20180406123607.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s007050050042 doi (NATIONALLICENCE)springer-10.1007/s007050050042 Molecular epidemiology of herpes simplex virus type 1 genital infection in association with clinical manifestations [Elektronische Daten] [K. Umene, T. Kawana] Summary.:  The antigenic types of herpes simplex virus (HSV), HSV-1 and HSV-2 are considered to be the etiology of genital herpes. Symptoms of primary HSV-1 and HSV-2 genital infections are similar, however, recurrence of the infection is less frequent after the HSV-1-related genital infection. We determined genotypes of 79 HSV-1 strains isolated from genital lesions in women (43 from primary and 36 from recurrent infections), by analyzing restriction fragment length polymorphism of the HSV-1 strains. Each proportion of genotypes of F1, F12, and F41 in strains isolated from recurrent genital lesions was higher than the corresponding proportion in strains from primary genital lesions. Genotypes of HSV-1 strains isolated two or more times from recurrent genital lesions of each of three subjects were genotye F1, thereby supporting the hypothesis that the F1 genotype is closely associated with recurrence. While the possibility of a genotype preference at the site of infection was not ruled out, genotypes of more than half the number of HSV-1 strains from genital lesions were the same as those from non-genital (mainly oral-facial) lesions analyzed in our foregoing studies, thus indicating that most HSV-1 genotypes are apparently shared by genital and non-genital lesions. 2000 Springer-Verlag/, Wien Umene K. Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan, JP aut Kawana T. Department of Obstetrics and Gynecology, Mizonokuchi Hospital,Teikyo University, Kawasaki, Japan, JP aut https://doi.org/10.1007/s007050050042 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050050042 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Umene K. Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan, JP aut NATIONALLICENCE 700 1- Kawana T. Department of Obstetrics and Gynecology, Mizonokuchi Hospital,Teikyo University, Kawasaki, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer