caa a22 4500 475766539 CHVBK 20180406123607.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s007050050045 doi (NATIONALLICENCE)springer-10.1007/s007050050045 Genetic variability of measles viruses circulating in the Benelux [Elektronische Daten] [F. Hanses, R. van Binnendijk, W. Ammerlaan, A. T. Truong, L. de Rond, F. Schneider, C. P. Muller] Summary.:  In Europe measles incidence remains high and in some parts the disease is likely to be still endemic due to insufficient vaccination. Luxembourg experienced an outbreak with at least 110 cases in 1996, and cases continued to be reported throughout 1997. We used molecular epidemiology to investigate this apparent endemicity. On the basis of their N gene sequences, the isolates were assigned to the typical European C2 and D6 genotypes. Sequence diversity within the outbreak was 0.2%. The nucleotide distance between the C2-viruses of the outbreak and the other C2 isolates was at least three or four times higher, suggesting an independent origin of the latter viruses. Similarly, the four D6 viruses found in Luxembourg were thought to be of at least two or three origins. Thus, we propose here to use intra-outbreak sequence diversity to differentiate between sporadic endemic cases and a "pseudo-outbreak” of multiple unrelated imported cases. 2000 Springer-Verlag/, Wien Hanses F. WHO Collaborating Center for Measles, Department of Immunology, Laboratoire National de Santé, Luxembourg, LU aut van Binnendijk R. Laboratory of Infectious Diseases, The National Institutes of Public Health and the Environment, The Netherlands, NL aut Ammerlaan W. WHO Collaborating Center for Measles, Department of Immunology, Laboratoire National de Santé, Luxembourg, LU aut Truong A. T. WHO Collaborating Center for Measles, Department of Immunology, Laboratoire National de Santé, Luxembourg, LU aut de Rond L. Laboratory of Infectious Diseases, The National Institutes of Public Health and the Environment, The Netherlands, NL aut Schneider F. WHO Collaborating Center for Measles, Department of Immunology, Laboratoire National de Santé, Luxembourg, LU aut Muller C. P. WHO Collaborating Center for Measles, Department of Immunology, Laboratoire National de Santé, Luxembourg, LU aut https://doi.org/10.1007/s007050050045 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050050045 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hanses F. WHO Collaborating Center for Measles, Department of Immunology, Laboratoire National de Santé, Luxembourg, LU aut NATIONALLICENCE 700 1- van Binnendijk R. Laboratory of Infectious Diseases, The National Institutes of Public Health and the Environment, The Netherlands, NL aut NATIONALLICENCE 700 1- Ammerlaan W. WHO Collaborating Center for Measles, Department of Immunology, Laboratoire National de Santé, Luxembourg, LU aut NATIONALLICENCE 700 1- Truong A. T. WHO Collaborating Center for Measles, Department of Immunology, Laboratoire National de Santé, Luxembourg, LU aut NATIONALLICENCE 700 1- de Rond L. Laboratory of Infectious Diseases, The National Institutes of Public Health and the Environment, The Netherlands, NL aut NATIONALLICENCE 700 1- Schneider F. WHO Collaborating Center for Measles, Department of Immunology, Laboratoire National de Santé, Luxembourg, LU aut NATIONALLICENCE 700 1- Muller C. P. WHO Collaborating Center for Measles, Department of Immunology, Laboratoire National de Santé, Luxembourg, LU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer