caa a22 4500 475766717 CHVBK 20180406123608.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s007050070050 doi (NATIONALLICENCE)springer-10.1007/s007050070050 The importance of the quasispecies nature of hepatitis C virus (HCV) for the evolution of HCV populations in patients: study on a single source outbreak of HCV infection [Elektronische Daten] [M. Lu, J. Kruppenbacher, M. Roggendorf] Summary.:  The quasispecies populations of hepatitis C virus (HCV) in the infectious source (IS) and in patients of a single source outbreak were characterized. A predominant variant AD78-1 and some minor variants of HCV 5′ NCR were identified in IS. Different complex HCV populations emerged rapidly in patients though HCV populations in chronic infection were rather simple and stable. AD78-1 remained predominant in 17/24 chronically infected patients while new predominant variants with distinct nucleotide substitutions persisted in 7 other patients. Thus, only distinct variants are involved in viral persistence and the genetic heterogeneity of HCV does not successively increase with time. Springer-Verlag/Wien, 2000 Lu M. Institut für Virologie, Universitätsklinikum Essen, Essen, Germany, DE aut Kruppenbacher J. Institut für Virologie, Universitätsklinikum Essen, Essen, Germany, DE aut Roggendorf M. Institut für Virologie, Universitätsklinikum Essen, Essen, Germany, DE aut https://doi.org/10.1007/s007050070050 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050070050 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lu M. Institut für Virologie, Universitätsklinikum Essen, Essen, Germany, DE aut NATIONALLICENCE 700 1- Kruppenbacher J. Institut für Virologie, Universitätsklinikum Essen, Essen, Germany, DE aut NATIONALLICENCE 700 1- Roggendorf M. Institut für Virologie, Universitätsklinikum Essen, Essen, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer