caa a22 4500 475766725 CHVBK 20180406123608.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s007050070047 doi (NATIONALLICENCE)springer-10.1007/s007050070047 Lack of disease-specific amino acid changes in the viral proteins of JC virus isolates from the brain with progressive multifocal leukoencephalopathy [Elektronische Daten] [A. Kato, C. Sugimoto, H.-Y. Zheng, T. Kitamura, Y. Yogo] Summary.:  Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system caused by a ubiquitous human polyomavirus designated as JC virus (JCV). JCVs in the brain of PML patients (PML-type JCVs) contain various regulatory regions generated from the archetypal regulatory region during persistence in the patients. We determined the complete DNA sequences of 2 PML-type isolates and 5 archetype isolates. Amino acid sequences of individual viral proteins were deduced from complete DNA sequences, and were compared among 16 isolates (6 PML types and 10 archetypes). From the data obtained, we concluded that PML-associated amino acid changes did not occur in the viral proteins of PML-type JCVs. Springer-Verlag/Wien, 2000 Kato A. Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, JP aut Sugimoto C. Department of Viral Infection, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, JP aut Zheng H.-Y Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, JP aut Kitamura T. Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, JP aut Yogo Y. Department of Viral Infection, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, JP aut https://doi.org/10.1007/s007050070047 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050070047 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kato A. Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Sugimoto C. Department of Viral Infection, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Zheng H.-Y Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Kitamura T. Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Yogo Y. Department of Viral Infection, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer