caa a22 4500 475767055 CHVBK 20180406123609.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s007050070083 doi (NATIONALLICENCE)springer-10.1007/s007050070083 Pathogenic avian adenovirus type II induces apoptosis in turkey spleen cells [Elektronische Daten] [S. Rautenschlein, M. Suresh, J. M. Sharma] Summary.:  Wild-type mammalian adenoviruses are known to inhibit programmed cells death in infected cells. This study demonstrated for the first time that an avian type II adenovirus, the hemorrhagic enteritis virus (HEV) of turkeys, induced apoptosis in turkey spleen cells at 3 and 4 days post infection. The increased apoptosis rate in spleens of HEV-infected turkeys was associated with increased virus replication. Increased apoptosis preceded extensive virus-induced cellular necrosis. At 3 days post infection, spleen cells from HEV-infected turkeys released tumor necrosis like factor and nitric oxide inducing factors after ex vivo stimulation with concanavalin A. Spleen cells from HEV-exposed turkeys also secreted an interleukin 6-like factor when cultured in vitro. These cytokines may have contributed to HEV-pathogenesis and HEV-induced apoptosis and necrosis in the spleen. Induction of apoptosis by an avian adenovirus but not by wild-type mammalian adenoviruses indicates that evolutionarily distant adenoviruses may have different pathogenic mechanisms. Springer-Verlag/Wien, 2000 Rautenschlein S. Department of Veterinary PathoBiology, University of Minnesota, St. Paul, Minnesota, U.S.A., US aut Suresh M. Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, U.S.A., US aut Sharma J. M. Department of Veterinary PathoBiology, University of Minnesota, St. Paul, Minnesota, U.S.A., US aut https://doi.org/10.1007/s007050070083 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050070083 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rautenschlein S. Department of Veterinary PathoBiology, University of Minnesota, St. Paul, Minnesota, U.S.A., US aut NATIONALLICENCE 700 1- Suresh M. Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, U.S.A., US aut NATIONALLICENCE 700 1- Sharma J. M. Department of Veterinary PathoBiology, University of Minnesota, St. Paul, Minnesota, U.S.A., US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer