caa a22 4500 47576708X CHVBK 20180406123609.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s007050050681 doi (NATIONALLICENCE)springer-10.1007/s007050050681 Precursor genes of future pandemic influenza viruses are perpetuated in ducks nesting in Siberia [Elektronische Daten] [K. Okazaki, A. Takada, T. Ito, M. Imai, H. Takakuwa, M. Hatta, H. Ozaki, T. Tanizaki, T. Nagano, A. Ninomiya, V. A. Demenev, M. M. Tyaptirganov, T. D. Karatayeva, S. S. Yamnikova, D. K. Lvov, H. Kida] Summary.:  Influenza A viruses of different subtypes were isolated from fecal samples of ducks in their nesting areas in Siberia in summer from 1996 to 1998. Phylogenetic analysis of the NP genes of the isolates in Siberia and those in Hokkaido, Japan on their flyway of migration from Siberia to the south in autumn revealed that they belong to the Eurasian lineage of avian influenza viruses. It is noted that the genes of the isolates in Siberia are closely related to those of H5N1 influenza virus strains isolated from chickens and humans in Hong Kong in 1997 as well as to those of isolates from domestic birds in southern China. The results indicate that influenza viruses perpetuated in ducks nesting in Siberia should have contributed genes in the emergence of the H5N1 virusin Hong Kong. Vaccine prepared from avirulent A/duck/Hokkaido/4/96 (H5N3) influenza virus was potent enough to protect mice from challenge with lethal dose of the pathogenic H5N1 virus [19]. Intensive surveillance study of aquatic birds especially in Siberia is, therefore, stressed to provide information on the future pandemic influenza virus strains and for vaccine preparation. Springer-Verlag, 2000 Okazaki K. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Takada A. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Ito T. Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut Imai M. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Takakuwa H. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Hatta M. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Ozaki H. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Tanizaki T. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Nagano T. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Ninomiya A. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Demenev V. A. Far-Eastern Medical Association, Khabarovsk, Russia, RU aut Tyaptirganov M. M. Department of Biology Resources, Ministry of Nature Protection, Yakutsk, Sakha Republic, Russia, RU aut Karatayeva T. D. Veterinary Department, Ministry of Agriculture and Food, Yakutsk, Sakha Republic, Russia, RU aut Yamnikova S. S. Ivanovsky Institute of Virology, Moscow, Russia, RU aut Lvov D. K. Ivanovsky Institute of Virology, Moscow, Russia, RU aut Kida H. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut Archives of Virology Springer-Verlag 145/5(2000-05-01), 885-893 0304-8608 145:5<885 2000 145 705 https://doi.org/10.1007/s007050050681 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050050681 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okazaki K. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Takada A. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Ito T. Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori, Japan, JP aut NATIONALLICENCE 700 1- Imai M. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Takakuwa H. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Hatta M. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Ozaki H. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Tanizaki T. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Nagano T. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Ninomiya A. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 700 1- Demenev V. A. Far-Eastern Medical Association, Khabarovsk, Russia, RU aut NATIONALLICENCE 700 1- Tyaptirganov M. M. Department of Biology Resources, Ministry of Nature Protection, Yakutsk, Sakha Republic, Russia, RU aut NATIONALLICENCE 700 1- Karatayeva T. D. Veterinary Department, Ministry of Agriculture and Food, Yakutsk, Sakha Republic, Russia, RU aut NATIONALLICENCE 700 1- Yamnikova S. S. Ivanovsky Institute of Virology, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Lvov D. K. Ivanovsky Institute of Virology, Moscow, Russia, RU aut NATIONALLICENCE 700 1- Kida H. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan, JP aut NATIONALLICENCE 773 0- Archives of Virology Springer-Verlag 145/5(2000-05-01), 885-893 0304-8608 145:5<885 2000 145 705 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer