caa a22 4500 475767225 CHVBK 20180406123609.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s007050050685 doi (NATIONALLICENCE)springer-10.1007/s007050050685 Can HCV affect the efficacy of anti-HIV treatment? [Elektronische Daten] [P. Filippini, N. Coppola, C. Scolastico, G. Liorre, R. Nocera, E. Sagnelli, F. Piccinino] Summary.:  To evaluate the impact of new antiretroviral combinations (HAART: Highly Active Anti Retroviral Therapy) on HCV replication and liver enzyme levels, we analysed the changes in HCV viremia and aminotransferase levels in HIV and HCV co-infected patients. Moreover, to evaluate the influence of HCV infection on the efficacy of HAART, we compared the virological, immunological and biochemical response to antiretroviral combinations in anti-HIV positive subjects with or without HCV infection. We enrolled eight consecutive outpatients with HIV-HCV coinfection and with indications for HAART (Group A). For each patient in group A, we selected an anti-HIV negative patient with indications for HAART, pair-matched for age, sex, risk factor for HIV infection, presumed duration of infection, number of CD4 cells, HIV viremia and treatment schedule (Group B). A statistically significant increase in CD4 in both groups was found at 1st, 3rd and 6th month of antiretroviral therapy. A decrease in HIV-RNA in both groups was observed at 1st and 6th month of treatment. The percentage of patients with undetectable HIV-RNA at the 1st month was higher in Group B than in Group A (8/8 vs. 3/8, p = 0.025). Basal HCV-RNA viremia was very high in each case and no variations during treatment were observed. During therapy the aminotransferase levels slightly decreased in Group A and consistently increased in Group B. In Group A the differences were not significant to the statistical analysis; in Group B the aminotransferase levels at 3st and 6th month were significantly higher than those observed at the baseline. Springer-Verlag, 2000 Filippini P. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut Coppola N. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut Scolastico C. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut Liorre G. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut Nocera R. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut Sagnelli E. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut Piccinino F. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut Archives of Virology Springer-Verlag 145/5(2000-05-01), 937-944 0304-8608 145:5<937 2000 145 705 https://doi.org/10.1007/s007050050685 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050050685 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Filippini P. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut NATIONALLICENCE 700 1- Coppola N. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut NATIONALLICENCE 700 1- Scolastico C. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut NATIONALLICENCE 700 1- Liorre G. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut NATIONALLICENCE 700 1- Nocera R. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut NATIONALLICENCE 700 1- Sagnelli E. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut NATIONALLICENCE 700 1- Piccinino F. Institute of Infectious Diseases, School of Medicine, Second University of Naples, Naples, Italy, IT aut NATIONALLICENCE 773 0- Archives of Virology Springer-Verlag 145/5(2000-05-01), 937-944 0304-8608 145:5<937 2000 145 705 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer