caa a22 4500 475767241 CHVBK 20180406123609.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s007050050692 doi (NATIONALLICENCE)springer-10.1007/s007050050692 Comparison of proviral accessory genes between long-term nonprogressors and progressors of human immunodeficiency virus type 1 infection [Elektronische Daten] [T. Yamada, A. Iwamoto] Summary.:  We compared proviral accessory gene sequences (nef, vpu, vpr, vif, rev, tat) of human immunodeficiency virus type 1 (HIV-1) in the peripheral blood mononuclear cells (PBMC) between seven long-term non-progressors (LTNP) and seven progressors. LTNP frequently harbored proviruses with mutated accessory genes, while almost all accessory genes were intact in progressors. Presence of quasispecies in attenuated viruses suggests that they were not just a fossil record of nonreplication proviruses. These attenuated viruses in LTNP may be the source of their strong immune response against HIV-1. Our result might have relevance to a design of potent therapeutic vaccines. Springer-Verlag, 2000 Yamada T. Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, Japan, JP aut Iwamoto A. Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, Japan, JP aut Archives of Virology Springer-Verlag 145/5(2000-05-01), 1021-1027 0304-8608 145:5<1021 2000 145 705 https://doi.org/10.1007/s007050050692 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050050692 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamada T. Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Iwamoto A. Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, Japan, JP aut NATIONALLICENCE 773 0- Archives of Virology Springer-Verlag 145/5(2000-05-01), 1021-1027 0304-8608 145:5<1021 2000 145 705 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer