caa a22 4500 475767527 CHVBK 20180406123610.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s007050070019 doi (NATIONALLICENCE)springer-10.1007/s007050070019 Latent herpes simplex virus-1 infection in SCID mice transferred with immune CD4+T cells: a new model for latency [Elektronische Daten] [H. Minagawa, Y. Yanagi] Summary.:  In C.B-17 severe combined immunodeficiency (SCID) mice, corneal challenge with herpes simplex virus-1 (HSV-1) KOS strain usually leads to fatal encephalitis. With the transfer of T cells from immunized BALB/c mice, these SCID mice developed a latent HSV-1 infection. In order to determine the responsible T cell subset, fractionated immune T cells were transferred. Those SCID mice transferred with immune CD4+T cell-enriched fraction developed latent HSV-1 infection in their trigeminal ganglia. Their splenocytes had an increased percentage of CD4+T cells and showed a proliferative response against HSV-1. The transfer of CD8+T cells increased survival in the acute infection, but their engraftment seemed less needed for latency than that of CD4+T cells. Mice that received immune serum survived without developing latent HSV-1 infection. Some latently infected SCID mice had anti-HSV antibodies while others did not, indicating that the engraftment of antibody-producing B cells was not required for latency. Thus, immune CD4+T cells were important for the survival of SCID mice with latent HSV-1 infection. This animal model should be useful for investigation of latency/reactivation of HSV-1. Springer-Verlag/Wien, 2000 Minagawa H. Department of Virology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, JP aut Yanagi Y. Department of Virology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, JP aut Archives of Virology Springer-Verlag 145/11(2000-12-01), 2259-2272 0304-8608 145:11<2259 2000 145 705 https://doi.org/10.1007/s007050070019 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050070019 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Minagawa H. Department of Virology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, JP aut NATIONALLICENCE 700 1- Yanagi Y. Department of Virology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, JP aut NATIONALLICENCE 773 0- Archives of Virology Springer-Verlag 145/11(2000-12-01), 2259-2272 0304-8608 145:11<2259 2000 145 705 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer