caa a22 4500 475767535 CHVBK 20180406123610.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s007050070030 doi (NATIONALLICENCE)springer-10.1007/s007050070030 Murine gammaherpesvirus M11 gene product inhibits apoptosis and is expressed during virus persistence [Elektronische Daten] [D. J. Roy, B. C. Ebrahimi, B. M. Dutia, A. A. Nash, J. P. Stewart] Summary.:  The murine gammaherpesvirus (MHV-68) M11 gene encodes a protein with BH1 domain homology to Bcl-2. We found that the M11 gene product (MHVBcl-2) protected murine epithelial cells from TNF-α induced apoptosis. M11 was transcribed during early lytic infection in vitro. During early infection of mice, M11 message was detected in spleen and lung along with lytic cycle messages. During persistence, lytic cycle gene expression was undetectable but M11 RNA was still present. This suggests that MHVBcl-2 promotes virus survival by protecting not only productively infected but also persistently infected cells from apoptotic death. Springer-Verlag/Wien, 2000 Roy D. J. Department of Veterinary Pathology, University of Edinburgh, Edinburgh, Scotland, U.K., GB aut Ebrahimi B. C. Department of Veterinary Pathology, University of Edinburgh, Edinburgh, Scotland, U.K., GB aut Dutia B. M. Department of Veterinary Pathology, University of Edinburgh, Edinburgh, Scotland, U.K., GB aut Nash A. A. Department of Veterinary Pathology, University of Edinburgh, Edinburgh, Scotland, U.K., GB aut Stewart J. P. Department of Veterinary Pathology, University of Edinburgh, Edinburgh, Scotland, U.K., GB aut Archives of Virology Springer-Verlag 145/11(2000-12-01), 2411-2420 0304-8608 145:11<2411 2000 145 705 https://doi.org/10.1007/s007050070030 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s007050070030 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roy D. J. Department of Veterinary Pathology, University of Edinburgh, Edinburgh, Scotland, U.K., GB aut NATIONALLICENCE 700 1- Ebrahimi B. C. Department of Veterinary Pathology, University of Edinburgh, Edinburgh, Scotland, U.K., GB aut NATIONALLICENCE 700 1- Dutia B. M. Department of Veterinary Pathology, University of Edinburgh, Edinburgh, Scotland, U.K., GB aut NATIONALLICENCE 700 1- Nash A. A. Department of Veterinary Pathology, University of Edinburgh, Edinburgh, Scotland, U.K., GB aut NATIONALLICENCE 700 1- Stewart J. P. Department of Veterinary Pathology, University of Edinburgh, Edinburgh, Scotland, U.K., GB aut NATIONALLICENCE 773 0- Archives of Virology Springer-Verlag 145/11(2000-12-01), 2411-2420 0304-8608 145:11<2411 2000 145 705 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer