caa a22 4500 475767675 CHVBK 20180406123610.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/PL00008188 doi (NATIONALLICENCE)springer-10.1007/PL00008188 NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos [Elektronische Daten] [O. Pabst, H. Herbrand, N. Takuma, Hans-Henning Arnold] Abstract : NKX2 genes in vertebrates encode a sub- family of homeodomain-containing transcription factors which regulate morphogenetic events and cell differentiation during embryogenesis. In mouse embryos several NKX2 genes are expressed in the ventral midline domains of the neuroectoderm, while other NKX2 genes are primarily expressed in the mesendoderm and mesendodermally derived organs, such as heart and gut. Within several patterning centers for tissue organization sonic hedgehog (Shh) is an important signal in the formation of ventral midline structures in vertebrate embryos. Here, we investigated the role of Shh in the embryonic expression of six different but closely related NKX2 genes in Shh null mutant mice. We found that expression of NKX2.1, NKX2.2, and NKX2.9 in neural domains requires Shh signaling, whereas NKX2.3, NKX2.5 and NKX2.6 expression in endoderm and mesoderm is independent of Shh. Springer-Verlag Berlin Heidelberg, 2000 Key words NKX2 gene expression nationallicence Sonic hedgehog mutant nationallicence Mouse development nationallicence Pabst O. Department of Cell and Molecular Biology, Technical University of Braunschweig, Spielmannstrasse 7, D-38106 Braunschweig, Germany E-mail: h.arnold@tu-bs.de Tel.: +49-531-3915735, Fax: +49-531-3918178, DE aut Herbrand H. Department of Cell and Molecular Biology, Technical University of Braunschweig, Spielmannstrasse 7, D-38106 Braunschweig, Germany E-mail: h.arnold@tu-bs.de Tel.: +49-531-3915735, Fax: +49-531-3918178, DE aut Takuma N. Department of Obstetrics and Gynecology, Asahikawa Medical College, Nishikagura 4-5-3-11, Asahikawa, 078-8510, Japan, JP aut Arnold Hans-Henning Department of Cell and Molecular Biology, Technical University of Braunschweig, Spielmannstrasse 7, D-38106 Braunschweig, Germany E-mail: h.arnold@tu-bs.de Tel.: +49-531-3915735, Fax: +49-531-3918178, DE aut https://doi.org/10.1007/PL00008188 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008188 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pabst O. Department of Cell and Molecular Biology, Technical University of Braunschweig, Spielmannstrasse 7, D-38106 Braunschweig, Germany E-mail: h.arnold@tu-bs.de Tel.: +49-531-3915735, Fax: +49-531-3918178, DE aut NATIONALLICENCE 700 1- Herbrand H. Department of Cell and Molecular Biology, Technical University of Braunschweig, Spielmannstrasse 7, D-38106 Braunschweig, Germany E-mail: h.arnold@tu-bs.de Tel.: +49-531-3915735, Fax: +49-531-3918178, DE aut NATIONALLICENCE 700 1- Takuma N. Department of Obstetrics and Gynecology, Asahikawa Medical College, Nishikagura 4-5-3-11, Asahikawa, 078-8510, Japan, JP aut NATIONALLICENCE 700 1- Arnold Hans-Henning Department of Cell and Molecular Biology, Technical University of Braunschweig, Spielmannstrasse 7, D-38106 Braunschweig, Germany E-mail: h.arnold@tu-bs.de Tel.: +49-531-3915735, Fax: +49-531-3918178, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer