caa a22 4500 475767705 CHVBK 20180406123610.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/PL00008186 doi (NATIONALLICENCE)springer-10.1007/PL00008186 Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster [Elektronische Daten] [M. J. Cann, L. R. Levin] Abstract : We have identified a novel isoform of adenylyl cyclase, DAC78C, in Drosophila melanogaster that encodes two structurally distinct proteins in a developmentally restricted manner. The protein corresponding to one transcript is potently activated by G protein and protein kinase C and is expressed ubiquitously. The protein corresponding to the second transcript is expressed in a dynamic pattern in gastrulation stage embryos; it is restricted to the cephalic furrow and dorsal transverse folds, active regions of cell movement of unknown function in the Drosophila embryo. We propose that DAC78C and the cAMP pathway play an important role in directing these morphogenetic movements, and that this gene may provide clues to the functional significance of these structures in gastrulation. Springer-Verlag Berlin Heidelberg, 2000 Key words Drosophila melanogaster nationallicence Adenylyl cyclase nationallicence Gastrulation nationallicence Cephalic furrow nationallicence Dorsal transverse folds nationallicence Cann M. J. Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue New York, NY 10021, USA E-mail: llevin@mail.med.cornell.edu Tel.: +1-212-7466752, Fax: +1-212-7468835, US aut Levin L. R. Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue New York, NY 10021, USA E-mail: llevin@mail.med.cornell.edu Tel.: +1-212-7466752, Fax: +1-212-7468835, US aut https://doi.org/10.1007/PL00008186 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008186 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cann M. J. Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue New York, NY 10021, USA E-mail: llevin@mail.med.cornell.edu Tel.: +1-212-7466752, Fax: +1-212-7468835, US aut NATIONALLICENCE 700 1- Levin L. R. Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue New York, NY 10021, USA E-mail: llevin@mail.med.cornell.edu Tel.: +1-212-7466752, Fax: +1-212-7468835, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer