caa a22 4500 47576773X CHVBK 20180406123611.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s004270050319 doi (NATIONALLICENCE)springer-10.1007/s004270050319 Activin A signaling directly activates Xenopus winged helix factors XFD-4/4', the orthologues to mammalian MFH-1 [Elektronische Daten] [M. Köster, K. Dillinger, W. Knöchel] Abstract : We investigated the Xenopus winged helix gene XFD-4, its cDNA, and a pseudoallelic cDNA, termed XFD-4', representing Xenopus orthologues to chicken CWH-2 and mammalian MFH-1. XFD-4/4' genes are activated after midblastula transition in dorsolateral mesoderm but not within the dorsal lip. Later, expression is found in two segmented lines of cells bordering the somites, in head mesenchyme, in ventral abdominal muscle, and in the tail tip. Smad2 RNA injection leads to ectopic expression of XFD-4'. Since activation is also observed in activin A treated animal cap explants in the presence of cycloheximide, XFD-4/4' genes represent direct targets of activin signaling. Note that the future nomenclature for XFD-4 will be FoxC2a and for XFD-4' will be FoxC2b (Fox Nomenclature Committee). Springer-Verlag Berlin Heidelberg, 2000 Key words Winged helix transcription factor nationallicence Xenopuslaevis nationallicence Paraxial mesoderm nationallicence Abdominal muscle nationallicence Activin A nationallicence Köster M. Abteilung Biochemie, Universität Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany E-mail: walter.knoechel@medizin.uni-ulm.de Tel.: +49-731-5023280, Fax: +49-731-5023277, DE aut Dillinger K. Abteilung Biochemie, Universität Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany E-mail: walter.knoechel@medizin.uni-ulm.de Tel.: +49-731-5023280, Fax: +49-731-5023277, DE aut Knöchel W. Abteilung Biochemie, Universität Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany E-mail: walter.knoechel@medizin.uni-ulm.de Tel.: +49-731-5023280, Fax: +49-731-5023277, DE aut https://doi.org/10.1007/s004270050319 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270050319 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Köster M. Abteilung Biochemie, Universität Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany E-mail: walter.knoechel@medizin.uni-ulm.de Tel.: +49-731-5023280, Fax: +49-731-5023277, DE aut NATIONALLICENCE 700 1- Dillinger K. Abteilung Biochemie, Universität Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany E-mail: walter.knoechel@medizin.uni-ulm.de Tel.: +49-731-5023280, Fax: +49-731-5023277, DE aut NATIONALLICENCE 700 1- Knöchel W. Abteilung Biochemie, Universität Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany E-mail: walter.knoechel@medizin.uni-ulm.de Tel.: +49-731-5023280, Fax: +49-731-5023277, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer