caa a22 4500 475767748 CHVBK 20180406123611.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s004270050315 doi (NATIONALLICENCE)springer-10.1007/s004270050315 The leech hunchback protein is expressed in the epithelium and CNS but not in the segmental precursor lineages [Elektronische Daten] [J.H. Iwasa, D.W. Suver, R.M. Savage] Abstract : We are interested in identifying the regulatory genes involved in segmental pattern formation in annelids. The Drosophila segmentation gene hunchback (hb) is critical for the proper anteroposterior development of the fly embryo, but its function outside the diptera is currently unknown. Here, the protein expression pattern of Leech Zinc Finger II (LZF2), a leech orthologue of hb is characterized. In early embryogenesis, LZF2 protein is expressed in a subset of micromeres and is later expressed in the micromere-derived epithelium of the provisional epithelium and prostomium. LZF2 protein is detected in the ventral nerve cord during organogenesis, first in interganglionic muscle cells and later in subsets of neurons in each neuromere of the CNS. The location of immunoreactive cells during development and the similarity of the expression pattern of LZF2 to the expression of the Caenhorhabditis elegans hb homologue hbl-1 suggests that LZF2 plays a role in the morphogenetic movements of leech gastrulation and later in CNS specification but not in anteroposterior pattern formation. Springer-Verlag Berlin Heidelberg, 2000 Key words Annelid nationallicence Hunchback nationallicence Anteroposterior patterning nationallicence Micromere nationallicence Iwasa J.H. Department of Biology, Williams College, Williamstown, MA 01267, USA E-mail: rsavage@williams.edu Tel.: +1-413-5973314, Fax: +1-413-5973495, US aut Suver D.W. Department of Biology, Williams College, Williamstown, MA 01267, USA E-mail: rsavage@williams.edu Tel.: +1-413-5973314, Fax: +1-413-5973495, US aut Savage R.M. Department of Biology, Williams College, Williamstown, MA 01267, USA E-mail: rsavage@williams.edu Tel.: +1-413-5973314, Fax: +1-413-5973495, US aut https://doi.org/10.1007/s004270050315 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270050315 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iwasa J.H. Department of Biology, Williams College, Williamstown, MA 01267, USA E-mail: rsavage@williams.edu Tel.: +1-413-5973314, Fax: +1-413-5973495, US aut NATIONALLICENCE 700 1- Suver D.W. Department of Biology, Williams College, Williamstown, MA 01267, USA E-mail: rsavage@williams.edu Tel.: +1-413-5973314, Fax: +1-413-5973495, US aut NATIONALLICENCE 700 1- Savage R.M. Department of Biology, Williams College, Williamstown, MA 01267, USA E-mail: rsavage@williams.edu Tel.: +1-413-5973314, Fax: +1-413-5973495, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer